ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

Ying Chen, Murat S. Durakoglugil, Xunde Xian, +1

Proceedings of the National Academy of Sciences

Brain DevelopmentSynaptic TransmissionNeurotransmitterMolecular BiologyNeurochemical Biomarkers +19

Suberoylanilide Hydroxamic Acid (Vorinostat) Up-regulates Progranulin Transcription

Basar Cenik, Chantelle F. Sephton, Colleen M. Dewey, +16

Journal of Biological Chemistry

Progranulin TranscriptionMolecular RegulationNeurochemical BiomarkersTranscriptional RegulationSignaling Pathway +15

Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice

Courtney Lane‐Donovan, Wen Mai Wong, Murat S. Durakoglugil, +4

Journal of Neuroscience

Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease

Xunde Xian, Theresa Pohlkamp, Murat S. Durakoglugil, +5

eLife

Apoe4 DiffersMolecular BiologyAlzheimer ’Synaptic SignalingAlzheimer's Disease +16

Spontaneous Atherosclerosis in Aged Lipoprotein Lipase–Deficient Mice With Severe Hypertriglyceridemia on a Normal Chow Diet

Xiaohong Zhang, Rong Qi, Xunde Xian, +7

Circulation Research

NutritionVascular DiseaseLpl-deficient MicePathologyHyperlipidemia +18

LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis

Xunde Xian, Yinyuan Ding, Marco Dieckmann, +8

eLife

Knockin Mouse ModelImmunologyHyperlipidemiaCellular PhysiologyInflammation +23

LDL Receptor Gene-ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia With Dominant Inheritance and Diet-induced Coronary Atherosclerosis

Xin Guo, Mingming Gao, Yunan Wang, +11

EBioMedicine

Low-Density Lipoprotein Receptor-Related Protein-1 Protects Against Hepatic Insulin Resistance and Hepatic Steatosis

Yinyuan Ding, Xunde Xian, William L. Holland, +2

EBioMedicine

Loss of Reelin protects against atherosclerosis by reducing leukocyte–endothelial cell adhesion and lesion macrophage accumulation

Yinyuan Ding, Linzhang Huang, Xunde Xian, +6

Science Signaling

Vascular DiseaseImmunologyPathologyReelin Promotes AtherosclerosisInflammation +19

Presynaptic Defects Underlying Impaired Learning and Memory Function in Lipoprotein Lipase-Deficient Mice

Xunde Xian, Tingting Liu, Jia Yu, +8

Journal of Neuroscience

Lipoprotein LipaseNeurochemical BiomarkersMetabolic SyndromeAlzheimer's DiseaseLipoprotein Lipase-deficient Mice +17