Alexander A. Constan

Metabolism of Chloroform by Cytochrome P450 2E1 Is Required for Induction of Toxicity in the Liver, Kidney, and Nose of Male Mice

Alexander A. Constan, Catherine S. Sprankle, Jeffrey M. Peters et al. · Toxicology and Applied Pharmacology · 1999 · 111 citations

Cytochrome P450 2E1, Biochemistry, Medicine +11

Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicologic interaction between carbon tetrachloride and Kepone

Hisham El‐Masri, Russell S. Thomas, G. Rob Sabados et al. · Archives of Toxicology · 1996 · 41 citations

Pharmacokinetic Modeling, Biochemistry, Carbon Tetrachloride +10

Physiologically based pharmacodynamic modeling of an interaction threshold between trichloroethylene and 1,1-dichloroethylene in fischer 344 rats

Hisham El‐Masri, Alexander A. Constan, Howard S. Ramsdell et al. · Toxicology and Applied Pharmacology · 1996 · 38 citations

Pharmacokinetic Modeling, Medicine, Physiology +10

Long-term mutagenicity studies with chloroform and dimethylnitrosamine in femalelacI transgenic B6C3F1 mice

Byron E. Butterworth, Michael V. Templin, Alexander A. Constan et al. · Environmental and Molecular Mutagenesis · 1998 · 29 citations

A unique pattern of hepatocyte proliferation in F344 rats following long-term exposures to low levels of a chemical mixture of groundwater contaminants

Alexander A. Constan, Raymond S. H. Yang, Dale C. Baker et al. · Carcinogenesis · 1995 · 21 citations