The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis

Iris Augustin, Violaine Goidts, Angelika Bongers, +8

EMBO Molecular Medicine

Potent antileukemic activity of curaxin CBL0137 against MLL‐rearranged leukemia

Klaartje Somers, Angelika Kosciolek, Angelika Bongers, +14

International Journal of Cancer

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

Klaartje Somers, Victoria W. Wen, Shiloh Middlemiss, +34

Oncogene

Effective targeting of NAMPT in patient-derived xenograft models of high-risk pediatric acute lymphoblastic leukemia

Klaartje Somers, Kathryn Evans, Leanna Cheung, +21

Leukemia

Hematological MalignancyTumor BiologyNovel TherapyPatient-derived Xenograft ModelsMedicine +8

Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma

Lin Xiao, Klaartje Somers, Jayne Murray, +35

Clinical Cancer Research

Exploiting the reactive oxygen species imbalance in high-risk paediatric acute lymphoblastic leukaemia through auranofin

Mawar Karsa, Angelika Kosciolek, Angelika Bongers, +13

British Journal of Cancer

Hematological MalignancyPediatric HematologyMedicineMalignant Blood DisorderImmunology +4

Suppression of the ABCA1 Cholesterol Transporter Impairs the Growth and Migration of Epithelial Ovarian Cancer

Jixuan Gao, MoonSun Jung, Rebekka Williams, +13

Cancers

<scp>ABCC4</scp>/<scp>MRP4</scp> contributes to the aggressiveness of Myc‐associated epithelial ovarian cancer

MoonSun Jung, Jixuan Gao, Leanna Cheung, +12

International Journal of Cancer

Tumor BiologyOncologyMrp4 Substrate DrugsEpithelial Ovarian CancerMedicine +12

CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with <i>MLL</i> rearrangements

Klaartje Somers, Daria A. Chudakova, Shiloh Middlemiss, +18

Oncotarget

Infant LeukemiaMixed-phenotype Acute LeukemiaImmunologyMolecular BiologyCytotoxic Activity +16

The Combination of Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Delays KMT2A-Rearranged Leukemia Progression

Lin Xiao, Mawar Karsa, Emma Ronca, +19

Frontiers in Oncology