Exomic Sequencing Identifies <i>PALB2</i> as a Pancreatic Cancer Susceptibility Gene

Siân Jones, Ralph H. Hruban, Mihoko Kamiyama, +16

Science

EngineeringPalb2 ProteinGeneticsGenetic EpidemiologyPathology +15

Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia

Mitsuro Kanda, Hanno Matthaei, Jian Wu, +8

Gastroenterology

Tumor BiologyPancreatic CancerSomatic MutationsSomatic VariantMedicine +5

Deleterious Germline Mutations in Patients With Apparently Sporadic Pancreatic Adenocarcinoma

Koji Shindo, Jun Yu, Masaya Suenaga, +19

Journal of Clinical Oncology

Cancer PathologyGeneticsPathologyTumor BiologyClinical Genetics +16

An achaete-scute homologue essential for neuroendocrine differentiation in the lung

Michael Borges, R. Ilona Linnoila, Helgi J. K. van de Velde, +5

Nature

Adrenal GlandMolecular PhysiologySignal TransductionDevelopmental BiologyCell Signaling +7

Notch signaling induces cell cycle arrest in small cell lung cancer cells.

Virote Sriuranpong, Michael Borges, Rajani Ravi, +4

PubMed

Cell DeathCancer BiologyTumor BiologySignaling PathwayCell Regulation +16

Conservation of the <i>Drosophila</i> lateral inhibition pathway in human lung cancer: A hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression

Herbert Chen, Arunthathi Thiagalingam, Hemi Chopra, +5

Proceedings of the National Academy of Sciences

Hairy-related ProteinCancer BiologyTumor BiologyTranscriptional RegulationSignaling Pathway +14

Pancreatic Cancers Epigenetically Silence <i>SIP1</i> and Hypomethylate and Overexpress <i>miR-200a/200b</i> in Association with Elevated Circulating <i>miR-200a</i> and <i>miR-200b</i> Levels

Ang Li, Noriyuki Omura, Seung‐Mo Hong, +5

Cancer Research

Epigenetic ChangeAberrant Dna MethylationPathologyCancer BiologyEpigenetics +16

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer

Erica J. Childs, Evelina Mocci, Daniele Campa, +59

Nature Genetics

Pancreatic CancerMedicinePathologyCancer GenomicsCommon Variation +6

Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors.

Douglas W. Ball, Christopher G. Azzoli, S B Baylin, +6

Proceedings of the National Academy of Sciences

Triplet Repeat AmplificationTriplet CagMolecular BiologyPathologyGenomic Mechanism +19

Mutant TP53 in Duodenal Samples of Pancreatic Juice From Patients With Pancreatic Cancer or High-Grade Dysplasia

Mitsuro Kanda, Yoshihiko Sadakari, Michael Borges, +11

Clinical Gastroenterology and Hepatology

Tumor BiologyHigh-grade DysplasiaPancreatic CancerMutant Tp53Medicine +6