Toshihiko Murayama

Loss of the inhibitory function of the guanine nucleotide regulatory component of adenylate cyclase due to its ADP ribosylation by islet-activating protein, pertussis toxin, in adipocyte membranes.

Toshihiko Murayama, M Ui · Journal of Biological Chemistry · 1983 · 406 citations · Full text

Studies on the Synthesis and Opioid Agonistic Activities of Mitragynine-Related Indole Alkaloids:  Discovery of Opioid Agonists Structurally Different from Other Opioid Ligands

Hiromitsu Takayama, Hayato Ishikawa, Mika Kurihara et al. · Journal of Medicinal Chemistry · 2002 · 264 citations · Full text

Medicinal Chemistry, Mitragyna Speciosa, Pharmacological Study +13

Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release in 3T3 fibroblasts. Selective susceptibility to islet-activating protein, pertussis toxin.

Toshihiko Murayama, M Ui · Journal of Biological Chemistry · 1985 · 244 citations · Full text

Phosphatidic acid may stimulate membrane receptors mediating adenylate cyclase inhibition and phospholipid breakdown in 3T3 fibroblasts.

Toshihiko Murayama, M Ui · Journal of Biological Chemistry · 1987 · 218 citations · Full text

Phosphatidic Acid, Lipid Peroxidation, Cellular Pharmacology +20

Changes in expressions of proinflammatory cytokines IL-1β, TNF-α and IL-6 in the brain of senescence accelerated mouse (SAM) P8

Kyi Kyi Tha, Yasunobu Okuma, Hiroyuki Miyazaki et al. · Brain Research · 2000 · 161 citations

Inflammation, Aging, Medicine +9