Novel Carbamates as Orally Active Acetylcholinesterase Inhibitors Found to Improve Scopolamine-Induced Cognition Impairment: Pharmacophore-Based Virtual Screening, Synthesis, and Pharmacology

Shailendra S. Chaudhaery, Kuldeep K. Roy, Neeraj Shakya, +5

Journal of Medicinal Chemistry

NeuropsychologyDrug TargetPharmacotherapyMedicinal ChemistryPharmacological Study +17

Development of 3D-QSAR models for 5-Lipoxygenase antagonists: chalcones

M. Arockia Babu, Neeraj Shakya, Philip Prathipati, +2

Bioorganic & Medicinal Chemistry

Molecular DockingBiochemistryMedicineRational Drug Design3D-qsar Models +2

Chemotherapeutic Interventions Against Tuberculosis

Neeraj Shakya, Gaurav Garg, Babita Agrawal, +1

Pharmaceuticals

Tuberculosis PreventionPharmacotherapyAntimicrobial ChemotherapyMetronomic ChemotherapyDrug Resistance +15

3′-Bromo Analogues of Pyrimidine Nucleosides as a New Class of Potent Inhibitors of<i>Mycobacterium tuberculosis</i>

Neeraj Shakya, Naveen C. Srivastav, Nancy Desroches, +3

Journal of Medicinal Chemistry

Tuberculosis PreventionMolecular BiologyAntimicrobial Chemotherapy3′-Bromo AnaloguesPharmaceutical Chemistry +17

Substituted 1,2,3,4-tetrahydroquinolin-6-yloxypropanes as β3-adrenergic receptor agonists: Design, synthesis, biological evaluation and pharmacophore modeling

Neeraj Shakya, Kuldeep K. Roy, Anil Kumar Saxena

Bioorganic & Medicinal Chemistry

Molecular PharmacologyBiochemistryMedicineMechanism Of ActionPharmacological Agent +8

Antiviral Activity of Various 1-(2′-Deoxy-β-<scp>d</scp>-lyxofuranosyl), 1-(2′-Fluoro-β-<scp>d</scp>-xylofuranosyl), 1-(3′-Fluoro-β-<scp>d</scp>-arabinofuranosyl), and 2′-Fluoro-2′,3′-didehydro-2′,3′-dideoxyribose Pyrimidine Nucleoside Analogues against Duck Hepatitis B Virus (DHBV) and Human Hepatitis B Virus (HBV) Replication

Naveen C. Srivastav, Neeraj Shakya, Michelle Mak, +3

Journal of Medicinal Chemistry

Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2′-‘up’ fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors

Neeraj Shakya, Naveen C. Srivastav, Sudha Bhavanam, +5

Bioorganic & Medicinal Chemistry

Antimicrobial Drug DiscoveryAntiviral CompoundMedicineDrug DiscoveryMycobacterium Tuberculosis +8

Antimycobacterial activities of 5-alkyl (or halo)-3′-substituted pyrimidine nucleoside analogs

Naveen C. Srivastav, Neeraj Shakya, Sudha Bhavanam, +5

Bioorganic & Medicinal Chemistry Letters

Antimycobacterial ActivitiesMedicinal ChemistryAntibacterial AgentAntimicrobial ChemotherapyAntimicrobial Compound +1

4′-Substituted pyrimidine nucleosides lacking 5′-hydroxyl function as potential anti-HCV agents

Neeraj Shakya, Satish Vedi, Chao Liang, +3

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBioorganic ChemistryBiochemistry4′-Substituted Pyrimidine NucleosidesMedicine +7

Investigation of C-5 alkynyl (alkynyloxy or hydroxymethyl) and/or N-3 propynyl substituted pyrimidine nucleoside analogs as a new class of antimicrobial agents

Saurabh Garg, Neeraj Shakya, Naveen C. Srivastav, +3

Bioorganic & Medicinal Chemistry

N-3 PropynylBiochemistryMedicineC-5 AlkynylNew Class +6