Use of Baricitinib in Patients With Moderate to Severe Coronavirus Disease 2019

Boghuma K Titanji, Monica M. Farley, Ashish Mehta, +9

Clinical Infectious Diseases

Ribonucleoside Triphosphates as Substrate of Human Immunodeficiency Virus Type 1 Reverse Transcriptase in Human Macrophages

Edward M. Kennedy, Christina Gavegnano, Laura A. Nguyen, +5

Journal of Biological Chemistry

Viral ReplicationBiochemistryHuman MacrophagesNatural SciencesPathogenesis +8

Ruxolitinib and Tofacitinib Are Potent and Selective Inhibitors of HIV-1 Replication and Virus Reactivation <i>In Vitro</i>

Christina Gavegnano, Mervi Detorio, Catherine Montero, +3

Antimicrobial Agents and Chemotherapy

Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors

Christina Gavegnano, Jessica H. Brehm, Franck P. Dupuy, +11

PLoS Pathogens

Immune RegulationImmunologyImmunodominanceAntiviral DrugViral Persistence +23

The Janus kinase inhibitor ruxolitinib reduces HIV replication in human macrophages and ameliorates HIV encephalitis in a murine model

Woldeab B. Haile, Christina Gavegnano, Sijia Tao, +3

Neurobiology of Disease

Human MacrophagesMedicineMurine ModelImmunologyAutophagy +8

Antiretroviral Monocyte Efficacy Score Linked to Cognitive Impairment in Hiv

Cecilia M. Shikuma, Beau K. Nakamoto, Bruce Shiramizu, +10

Antiviral Therapy

Baricitinib reverses HIV-associated neurocognitive disorders in a SCID mouse model and reservoir seeding in vitro

Christina Gavegnano, Woldeab B. Haile, Selwyn J. Hurwitz, +4

Journal of Neuroinflammation

Randomized Trial of Ruxolitinib in Antiretroviral-Treated Adults With Human Immunodeficiency Virus

Vincent C. Marconi, Carlee Moser, Christina Gavegnano, +16

Clinical Infectious Diseases

Simultaneous Quantification of Intracellular Natural and Antiretroviral Nucleosides and Nucleotides by Liquid Chromatography−Tandem Mass Spectrometry

Emilie Fromentin, Christina Gavegnano, Aleksandr Obikhod, +1

Analytical Chemistry

Abundant Non-canonical dUTP Found in Primary Human Macrophages Drives Its Frequent Incorporation by HIV-1 Reverse Transcriptase

Edward M. Kennedy, Waaqo Daddacha, Rebecca Slater, +4

Journal of Biological Chemistry

Viral ReplicationFrequent IncorporationImmunologyImmunodominanceCd4 T Cell Responses +16