Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

Lajos Mátés, Marinee Chuah, Eyayu Belay, +16

Nature Genetics

Natural SciencesGeneticsEvolutionary BiologySynthetic BiologyBeauty Transposase +7

Comparative Analysis of Transposable Element Vector Systems in Human Cells

Ivana Grabundžija, Markus Irgang, Lajos Mátés, +10

Molecular Therapy

Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk

Janka Mátrai, Alessio Cantore, Cynthia C. Bartholomae, +17

Hepatology

Hyperfunctional coagulation factor IX improves the efficacy of gene therapy in hemophilic mice

Alessio Cantore, Nisha Nair, Patrizia Della Valle, +9

Blood

Liver-Specific Transcriptional Modules Identified by Genome-Wide In Silico Analysis Enable Efficient Gene Therapy in Mice and Non-Human Primates

Marinee Chuah, Inge Petrus, Pieter De Bleser, +19

Molecular Therapy

Understanding the Role of Defective Invertases in Plants: Tobacco Nin88 Fails to Degrade Sucrose 

Katrien Le Roy, Rudy Vergauwen, Tom Struyf, +5

PLANT PHYSIOLOGY

Novel Hyperactive Transposons for Genetic Modification of Induced Pluripotent and Adult Stem Cells: A Nonviral Paradigm for Coaxed Differentiation  

Eyayu Belay, Janka Mátrai, Abel Acosta‐Sanchez, +15

Stem Cells

Regenerative MedicineEmbryonic Stem CellCoaxed DifferentiationInduced Pluripotent Stem CellDevelopmental Biology +13

Genome-wide Computational Analysis Reveals Cardiomyocyte-specific Transcriptional Cis-regulatory Motifs That Enable Efficient Cardiac Gene Therapy

Melvin Y. Rincón, Shilpita Sarcar, Dina Danso‐Abeam, +10

Molecular Therapy

Combined molecular and supramolecular bottom-up nanoengineering for enhanced nonlinear optical response: Experiments, modeling, and approaching the fundamental limit

Javier Pérez‐Moreno, Inge Asselberghs, Kai Song, +10

The Journal of Chemical Physics

Inclusion ComplexSupramolecular AssemblyEngineeringBottom-up SynthesisNonlinear Optics +18

An alternate sucrose binding mode in the E203Q <i>Arabidopsis</i> invertase mutant: An X‐ray crystallography and docking study

Janka Mátrai, Willem Lammens, Abel Jonckheer, +4

Proteins Structure Function and Bioinformatics

Catalytic PocketMolecular BiologyPlant Molecular BiologyBiosynthesisProtein Folding +14