Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

Prabhu S. Arunachalam, Florian Wimmers, Chris Ka Pun Mok, +28

Science

Viral DiagnosticsImmunodeficienciesInnate Immune SystemImmunologyImmune Regulation +27

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

Kimberly M. Cirelli, Diane G. Carnathan, Bartek Nogal, +31

Cell

VaccinationGerminal Center ResponsesHuman RetrovirusImmunologyAntiviral Therapy +6

Type I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures

Abigail Vanderheiden, Philipp Ralfs, Tatiana Chirkova, +18

Journal of Virology

Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo

Christopher C. Nixon, Maud Mavigner, Gavin C. Sampey, +40

Nature

Viral PersistenceHuman RetrovirusImmunodeficienciesImmune RegulationImmunology +12

Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

Timothy N. Hoang, María Pino, Arun K. Boddapati, +42

Cell

InflammationCytokineBaricitinib TreatmentLung InflammationInnate Immune System +6

Cache Domains That are Homologous to, but Different from PAS Domains Comprise the Largest Superfamily of Extracellular Sensors in Prokaryotes

Amit A. Upadhyay, Aaron D. Fleetwood, Ogün Adebalı, +2

PLoS Computational Biology

Largest SuperfamilySignal RecognitionMolecular BiologyDesignated Sensory DomainCellular Receptors +19

The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen

Colin Havenar‐Daughton, Anita Sarkar, Daniel W. Kulp, +20

Science Translational Medicine

How Bacterial Chemoreceptors Evolve Novel Ligand Specificities

Vadim M. Gumerov, Míriam Rico‐Jiménez, Marharyta Petukh, +5

mBio

A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs

Nanda Kishore Routhu, Narayanaiah Cheedarla, Sailaja Gangadhara, +29

Immunity

VaccinationVaccine DevelopmentImmune PathologySars-cov-2 InfectionImmunology +4

BALDR: a computational pipeline for paired heavy and light chain immunoglobulin reconstruction in single-cell RNA-seq data

Amit A. Upadhyay, Robert C. Kauffman, Amber Wolabaugh, +12

Genome Medicine