Christopher S. Lyle

Inhibition of Cell Proliferation and Cell Cycle Progression by Specific Inhibition of Basal JNK Activity

Lihua Du, Christopher S. Lyle, Toria B. Obey et al. · Journal of Biological Chemistry · 2004 · 144 citations · Full text

The JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin, and etoposide

Cheryl Brantley-Finley, Christopher S. Lyle, Lihua Du et al. · Biochemical Pharmacology · 2003 · 134 citations

Tumor Biology, Medicine, Apoptosis +13

Characterization of vinblastine-induced Bcl-xL and Bcl-2 phosphorylation: evidence for a novel protein kinase and a coordinated phosphorylation/dephosphorylation cycle associated with apoptosis induction

Lihua Du, Christopher S. Lyle, Timothy C. Chambers · Oncogene · 2004 · 80 citations

Signal Transduction, Novel Protein Kinase, Apoptosis Induction +9

Distinct signaling pathways of microtubule inhibitors – vinblastine and Taxol induce JNK‐dependent cell death but through AP‐1‐dependent and AP‐1‐independent mechanisms, respectively

David Terrano, Christopher S. Lyle, Kanaga Sabapathy et al. · FEBS Journal · 2008 · 59 citations

Vinblastine-induced Apoptosis Is Mediated by Discrete Alterations in Subcellular Location, Oligomeric Structure, and Activation Status of Specific Bcl-2 Family Members

Meenakshi Upreti, Christopher S. Lyle, Brian Skaug et al. · Journal of Biological Chemistry · 2006 · 40 citations · Full text

Vinblastine-induced Apoptosis Is, Discrete Alterations, Cell Regulation +15