Molecular predictors of prevention of recurrence in HCC with sorafenib as adjuvant treatment and prognostic factors in the phase 3 STORM trial

Roser Pinyol, Robert Montal, Laia Bassaganyas, +27

Gut

Massive parallel sequencing uncovers actionable FGFR2–PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma

Daniela Sia, Bojan Losic, Agrin Moeini, +20

Nature Communications

Molecular classification and therapeutic targets in extrahepatic cholangiocarcinoma

Robert Montal, Daniela Sia, Carla Montironi, +26

Journal of Hepatology

Tumor BiologyHepatologyMedicineHepatobiliary TumorBiliary Cancer +6

Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade

Eduardo Bonavita, Christian P. Bromley, Gustav Jonsson, +17

Immunity

Anti-Inflammatory Drugs Remodel the Tumor Immune Environment to Enhance Immune Checkpoint Blockade Efficacy

Victoria S. Pelly, Agrin Moeini, Lisanne M. Roelofsen, +12

Cancer Discovery

Molecular characterisation of hepatocellular carcinoma in patients with non-alcoholic steatohepatitis

Roser Pinyol, Sara Torrecilla, Huan Wang, +32

Journal of Hepatology

Metabolic Associated SteatohepatitisMolecular CharacterisationHepatologyNonalcoholic Fatty Liver DiseaseMedicine +13

Tumour initiating cells and IGF/FGF signalling contribute to sorafenib resistance in hepatocellular carcinoma

Victoria Tovar, Helena Cornellà, Agrin Moeini, +14

Gut

Trunk mutational events present minimal intra- and inter-tumoral heterogeneity in hepatocellular carcinoma

Sara Torrecilla, Daniela Sia, Andrew Harrington, +15

Journal of Hepatology

Trunk Mutational EventsHepatologyTumor HeterogeneityInter-tumoral HeterogeneityPathology +9

Mixed hepatocellular cholangiocarcinoma tumors: Cholangiolocellular carcinoma is a distinct molecular entity

Agrin Moeini, Daniela Sia, Zhongyang Zhang, +12

Journal of Hepatology

HepatologyBiliary TractBiliary CancerHistopathologyPathology +7

IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models

Iris Martinez-Quetglas, Roser Pinyol, Daniel Dauch, +13

Gastroenterology