Mouse Homologue of coq7/clk-1, Longevity Gene in Caenorhabditis elegans, Is Essential for Coenzyme Q Synthesis, Maintenance of Mitochondrial Integrity, and Neurogenesis

Daisuke Nakai, Shigeki Yuasa, Mayumí Takáhashi, +9

Biochemical and Biophysical Research Communications

BiologyMouse HomologueLongevity GeneLifespan ExtensionMitochondrial Biogenesis +8

High Glucose-Induced Upregulation of Osteopontin Is Mediated via Rho/Rho Kinase Pathway in Cultured Rat Aortic Smooth Muscle Cells

Harukiyo Kawamura, Koutaro Yokote, Sunao Asaumi, +5

Arteriosclerosis Thrombosis and Vascular Biology

Targeted Disruption of TGF-β–Smad3 Signaling Leads to Enhanced Neointimal Hyperplasia With Diminished Matrix Deposition in Response to Vascular Injury

Kazuki Kobayashi, Koutaro Yokote, Masaki Fujimoto, +9

Circulation Research

ImmunologyPathologyVascular SmcTumor BiologyTgf-β–smad3 Signaling +16

Hyperglycemia-induced alteration of vascular smooth muscle phenotype

Seijiro Mori, Minoru Takemoto, Koutaro Yokote, +2

Journal of Diabetes and its Complications

Metabolic SyndromeVascular AdaptationPhysiologyDiabetesVascular Biology +6

Enhanced intra-abdominal visceral fat accumulation in patients with Werner's syndrome

Seijiro Mori, S. Murano, Koutaro Yokote, +4

International Journal of Obesity

ObesityMetabolic SyndromeBody CompositionMetabolic DisorderGastroenterology +5

Orthologues of the Caenorhabditis elegans Longevity Gene clk-1 in Mouse and Human

Sunao Asaumi, Hidehito Kuroyanagi, Naohiko Seki, +1

Genomics

Lifespan ExtensionCell LineageDevelopmental BiologyLongevityGenetics +4

NK‐104, a 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitor, reduces osteopontin expression by rat aortic smooth muscle cells

Minoru Takemoto, Masaki Kitahara, Koutaro Yokote, +4

British Journal of Pharmacology

Identification and characterization of high glucose and glucosamine responsive element in the rat osteopontin promoter

Sunao Asaumi, Minoru Takemoto, Koutaro Yokote, +8

Journal of Diabetes and its Complications

BiochemistryHigh GlucoseGlucosamine Responsive ElementBone Morphogenic ProteinPhysiology +8

Mouse coq7/clk-1 Orthologue Rescued Slowed Rhythmic Behavior and Extended Life Span of clk-1 Longevity Mutant in Caenorhabditis elegans

Mayumí Takáhashi, Sunao Asaumi, Shuji Honda, +6

Biochemical and Biophysical Research Communications

BiologyLifespan ExtensionDevelopmental BiologyLongevityClk-1 Longevity Mutant +4

Differential Interaction of CrkII Adaptor Protein with Platelet-Derived Growth Factor α- and β-Receptors Is Determined by Its Internal Tyrosine Phosphorylation

Tarô Matsumoto, Koutaro Yokote, Ayako Take, +6

Biochemical and Biophysical Research Communications

Signal TransductionSignaling PathwayInternal Tyrosine PhosphorylationCell SignalingMedicine +10