Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis

Xueying Ren, Yanchun Li, Yi Zhou, +12

Redox Biology

Chemoprevention StrategyPathologyCell DeathCancer BiologyRedox Biology +19

Identification of Frataxin as a regulator of ferroptosis

Jing Du, Yi Zhou, Yanchun Li, +15

Redox Biology

DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism

Jing Du, Xu Wang, Yanchun Li, +11

Cell Death and Disease

FTH promotes the proliferation and renders the HCC cells specifically resist to ferroptosis by maintaining iron homeostasis

Wanye Hu, Chaoting Zhou, Qiangan Jing, +11

Cancer Cell International

CISD3 inhibition drives cystine-deprivation induced ferroptosis

Yanchun Li, Xin Wang, Zhihui Huang, +7

Cell Death and Disease

Inhibiting the compensatory elevation of xCT collaborates with disulfiram/copper-induced GSH consumption for cascade ferroptosis and cuproptosis

Ping Zhang, Chaoting Zhou, Xueying Ren, +14

Redox Biology

Functional deficiency of succinate dehydrogenase promotes tumorigenesis and development of clear cell renal cell carcinoma through weakening of ferroptosis

Jing Yang, Yi Zhou, Yanchun Li, +10

Bioengineered

Succinate DehydrogenasePathologyRedox BiologyTumor BiologyOxidative Stress +14

Downregulation of CISD2 Has Prognostic Value in Non-Small Cell Lung Cancer and Inhibits the Tumorigenesis by Inducing Mitochondrial Dysfunction

Fangchun Shao, Yanchun Li, Wanye Hu, +5

Frontiers in Oncology

OncologyMitochondrial BiogenesisMitochondrial FunctionMitochondrial DysfunctionMedicine +11

GSH exhaustion via inhibition of xCT-GSH-GPX4 pathway synergistically enhanced DSF/Cu-induced cuproptosis in myelodysplastic syndromes

Yanchun Li, Yanhua Yu, Xueying Ren, +12

Free Radical Biology and Medicine

Hematological MalignancyBone Marrow FailureMalignant Blood DisorderImmunologyHematology +8

TEOA Promotes Autophagic Cell Death via ROS-Mediated Inhibition of mTOR/p70S6k Signaling Pathway in Pancreatic Cancer Cells

Chen Yang, Yanchun Li, Wanye Hu, +7

Frontiers in Cell and Developmental Biology

Chemoprevention StrategyMitochondrial DysfunctionApoptosisImmunologyCell Death +16