Reshma Thamkachy

PLK1-mediated phosphorylation cascade activates Mis18 complex to ensure centromere inheritance

Pragya Parashara, Bethan Medina‐Pritchard, Maria Alba Abad et al. · Science · 2024 · 31 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

ERK mediated upregulation of death receptor 5 overcomes the lack of p53 functionality in the diaminothiazole DAT1 induced apoptosis in colon cancer models: efficiency of DAT1 in Ras-Raf mutated cells

Reshma Thamkachy, Rohith Kumar, Kallikat N. Rajasekharan et al. · Molecular Cancer · 2016 · 16 citations · Full text

Life Sciences, Oncology, Pharmacology +17

Structural basis for Mis18 complex assembly and its implications for centromere maintenance

Reshma Thamkachy, Bethan Medina‐Pritchard, Sang Ho Park et al. · EMBO Reports · 2024 · 13 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Upregulation of DR5 receptor by the diaminothiazole DAT1 [4-amino-5-benzoyl-2-(4-methoxy phenyl amino) thiazole] triggers an independent extrinsic pathway of apoptosis in colon cancer cells with compromised pro and antiapoptotic proteins

Sannu A. Thomas, Smreti Vasudevan, Reshma Thamkachy et al. · APOPTOSIS · 2013 · 12 citations

Life Sciences, Oncology, Pharmacology +17

Reversible Action of Diaminothiazoles in Cancer Cells Is Implicated by the Induction of a Fast Conformational Change of Tubulin and Suppression of Microtubule Dynamics

Nisha E. Thomas, Reshma Thamkachy, Krishnankutty C. Sivakumar et al. · Molecular Cancer Therapeutics · 2013 · 11 citations

Medicine, Oncology, Pharmacology +17