Identification of liver-specific enhancer–promoter activity in the 3′ untranslated region of the wild-type AAV2 genome

Grant J. Logan, Allison Dane, Claus V. Hallwirth, +14

Nature Genetics

Liver-specific Enhancer–promoter ActivityTranscriptional RegulationUntranslated RegionNatural SciencesGenetics +9

High-Throughput <i>In Vitro</i> , <i>Ex Vivo,</i> and <i>In Vivo</i> Screen of Adeno-Associated Virus Vectors Based on Physical and Functional Transduction

Adrian Westhaus, Marti Cabanes‐Creus, Arkadiusz Rybicki, +17

Human Gene Therapy

Restoring the natural tropism of AAV2 vectors for human liver

Marti Cabanes‐Creus, Claus V. Hallwirth, Adrian Westhaus, +16

Science Translational Medicine

Attenuation of Heparan Sulfate Proteoglycan Binding Enhances In Vivo Transduction of Human Primary Hepatocytes with AAV2

Marti Cabanes‐Creus, Adrian Westhaus, Renina Gale Navarro, +16

Molecular Therapy — Methods & Clinical Development

Long-term ex situ normothermic perfusion of human split livers for more than 1 week

Ngee‐Soon Lau, Mark Ly, Claude V. Dennis, +14

Nature Communications

Ex SituTransplantation SurgeryXenotransplantationHepatologySolid Organ Transplantation +13

Novel human liver-tropic AAV variants define transferable domains that markedly enhance the human tropism of AAV7 and AAV8

Marti Cabanes‐Creus, Renina Gale Navarro, Erhua Zhu, +11

Molecular Therapy — Methods & Clinical Development

Codon-Optimization of Wild-Type Adeno-Associated Virus Capsid Sequences Enhances DNA Family Shuffling while Conserving Functionality

Marti Cabanes‐Creus, Samantha L. Ginn, Anais K. Amaya, +13

Molecular Therapy — Methods & Clinical Development

Liver splitting during normothermic machine perfusion: a novel method to combine the advantages of both in-situ and ex-vivo techniques

Ngee‐Soon Lau, Mark Ly, Claude V. Dennis, +12

HPB

Novel MethodHepatologyLiver PhysiologyNormothermic Machine PerfusionOrgan Preservation +10

Single amino acid insertion allows functional transduction of murine hepatocytes with human liver tropic AAV capsids

Marti Cabanes‐Creus, Renina Gale Navarro, Sophia H.Y. Liao, +7

Molecular Therapy — Methods & Clinical Development

Harnessing whole human liver ex situ normothermic perfusion for preclinical AAV vector evaluation

Marti Cabanes‐Creus, Sophia H.Y. Liao, Renina Gale Navarro, +18

Nature Communications