A gene expression signature of retinoblastoma loss-of-function is a predictive biomarker of resistance to palbociclib in breast cancer cell lines and is prognostic in patients with ER positive early breast cancer

Luca Malorni, Silvano Piazza, Yari Ciani, +7

Oncotarget

Cyclin E1 and Rb modulation as common events at time of resistance to palbociclib in hormone receptor-positive breast cancer

Cristina Guarducci, Martina Bonechi, Matteo Benelli, +10

npj Breast Cancer

Activation of the IFN Signaling Pathway is Associated with Resistance to CDK4/6 Inhibitors and Immune Checkpoint Activation in ER-Positive Breast Cancer

Carmine De Angelis, Xiaoyong Fu, Maria Letizia Cataldo, +27

Clinical Cancer Research

Plasma thymidine kinase-1 activity predicts outcome in patients with hormone receptor positive and HER2 negative metastatic breast cancer treated with endocrine therapy

Martina Bonechi, Francesca Galardi, Chiara Biagioni, +10

Oncotarget

Circulating tumor cells and palbociclib treatment in patients with ER-positive, HER2-negative advanced breast cancer: results from a translational sub-study of the TREnd trial

Francesca Galardi, Francesca De Luca, Chiara Biagioni, +16

Breast Cancer Research

Selective CDK7 Inhibition Suppresses Cell Cycle Progression and MYC Signaling While Enhancing Apoptosis in Therapy-resistant Estrogen Receptor–positive Breast Cancer

Cristina Guarducci, Agostina Nardone, Douglas Russo, +28

Clinical Cancer Research

TransCONFIRM: Identification of a Genetic Signature of Response to Fulvestrant in Advanced Hormone Receptor–Positive Breast Cancer

Rinath Jeselsohn, William T. Barry, Ilenia Migliaccio, +10

Clinical Cancer Research

A gene expression signature of Retinoblastoma loss-of-function predicts resistance to neoadjuvant chemotherapy in ER-positive/HER2-positive breast cancer patients

Emanuela Risi, Andrea Grilli, Ilenia Migliaccio, +10

Breast Cancer Research and Treatment

Gene Expression SignatureBreast OncologyMedicineCancer GenomicsBreast Cancer +8

A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer

Agostina Nardone, Xintao Qiu, Sándor Spisák, +25

Cancer Research

Abstract PD7-12: Inhibition of CDK7 overcomes resistance to CDK4/6 inhibitors in hormone receptor positive breast cancer cells

Cristina Guarducci, Agostina Nardone, Ariel Feiglin, +9

Cancer Research

Metastatic Breast CancerBreast OncologyRb LossAbstract Pd7-12Medicine +13