Huizhen Wen

FCPR03, a novel phosphodiesterase 4 inhibitor, alleviates cerebral ischemia/reperfusion injury through activation of the AKT/GSK3β/ β-catenin signaling pathway

Bingtian Xu, Tiantian Wang, Jiao Xiao et al. · Biochemical Pharmacology · 2019 · 62 citations

Medicine, Neuroscience, Pharmacology +14

Inhibition of PDE4 by FCPR16 induces AMPK-dependent autophagy and confers neuroprotection in SH-SY5Y cells and neurons exposed to MPP+-induced oxidative insult

Jiahong Zhong, Jinfeng Xie, Xiao Jiao et al. · Free Radical Biology and Medicine · 2019 · 46 citations

Life Sciences, Neuroscience, Pharmacology +12

Inhibition of PDE4 Attenuates TNF-α-Triggered Cell Death Through Suppressing NF-κB and JNK Activation in HT-22 Neuronal Cells

Jiao Xiao, Rumeng Yao, Bingtian Xu et al. · Cellular and Molecular Neurobiology · 2019 · 30 citations · Full text

Life Sciences, Neuroscience, Pharmacology +15

PDE4 inhibition alleviates HMGB1/C1q/C3-mediated excessive phagocytic pruning of synapses by microglia and depressive-like behaviors in mice

Qian Zhao, Chunyuan Zeng, Fulan Luo et al. · Brain Behavior and Immunity · 2025 · 15 citations

Life Sciences, Neuroscience, Pharmacology +16

Inhibition of Phosphodiesterase 4 Suppresses Neuronal Ferroptosis After Cerebral Ischemia/Reperfusion

Kechun Chen, Bingtian Xu, Lu Long et al. · Molecular Neurobiology · 2024 · 12 citations

Medicine, Neurobiology, Neuroscience +16