Making a definitive diagnosis: Successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease

Elizabeth A. Worthey, Alan N. Mayer, Grant Syverson, +19

Genetics in Medicine

Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids

Sarah J. Hill, Brennan Decker, Emma A. Roberts, +19

Cancer Discovery

Cancer Risks Associated With Germline<i>PALB2</i>Pathogenic Variants: An International Study of 524 Families

Xin Yang, Goska Leslie, Alicja Doroszuk, +114

Journal of Clinical Oncology

Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology

Jocelyn Plassais, Jaemin Kim, Brian W. Davis, +6

Nature Communications

Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens

Geoffrey M. Lynn, Christine Sedlik, Faezzah Baharom, +27

Nature Biotechnology

VaccinationNanomedicineCross-protectionTumor ImmunologyImmunology +10

Variation of BMP3 Contributes to Dog Breed Skull Diversity

Jeffrey J. Schoenebeck, Sarah A. Hutchinson, Alexandra Byers, +13

PLoS Genetics

Animal StudyDevelopmental BiologyQuantitative GeneticsBmp3 FunctionMedicine +13

Homologous Mutation to Human BRAF V600E Is Common in Naturally Occurring Canine Bladder Cancer—Evidence for a Relevant Model System and Urine-Based Diagnostic Test

Brennan Decker, Heidi G. Parker, Deepika Dhawan, +8

Molecular Cancer Research

No evidence that protein truncating variants in <i>BRIP1</i> are associated with breast cancer risk: implications for gene panel testing

Douglas F. Easton, Fabienne Lesueur, Brennan Decker, +22

Journal of Medical Genetics

Rare, protein-truncating variants in <i>ATM</i>, <i>CHEK2</i> and <i>PALB2</i>, but not <i>XRCC2</i>, are associated with increased breast cancer risks

Brennan Decker, Jamie Allen, Craig Luccarini, +13

Journal of Medical Genetics

Tumor Fraction Correlates With Detection of Actionable Variants Across &gt; 23,000 Circulating Tumor DNA Samples

Hatim Husain, Dean C. Pavlick, Bernard J. Fendler, +11

JCO Precision Oncology