Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy

João Incio, Hao Liu, Priya Suboj, +24

Cancer Discovery

Solid stress and elastic energy as measures of tumour mechanopathology

Hadi T. Nia, Hao Liu, Giorgio Seano, +16

Nature Biomedical Engineering

MechanobiologyNonlinear ElasticitySolid StressEngineeringElasticity (Physics) +8

Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution

Raghu P. Kataru, Keehoon Jung, Cholsoon Jang, +6

Blood

Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

Jonas Kloepper, Lars Riedemann, Zohreh Amoozgar, +24

Proceedings of the National Academy of Sciences

Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages

Teresa Peterson, Nathaniel D. Kirkpatrick, Yuhui Huang, +20

Proceedings of the National Academy of Sciences

ImmunologyGbm Patients ReboundHigh-grade GliomasGliomaTumor Biology +14

Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases

Nuh N. Rahbari, Dmitriy Kedrin, João Incio, +19

Science Translational Medicine

Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2

João Incio, Jennifer A. Ligibel, Daniel T. McManus, +22

Science Translational Medicine

Breast OncologyImmunologyPathologyTumor BiologyObesity Prevention +16

Endoscopic Time-Lapse Imaging of Immune Cells in Infarcted Mouse Hearts

Keehoon Jung, Pilhan Kim, Florian Leuschner, +5

Circulation Research

Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy

Keehoon Jung, Takahiro Heishi, Omar F. Khan, +13

Journal of Clinical Investigation

ImmunologyImmunoeditingCurrent Anti-vegf TherapiesDrive ImmunosuppressionImmunotherapy +14

Double Antiangiogenic Protein, DAAP, Targeting VEGF-A and Angiopoietins in Tumor Angiogenesis, Metastasis, and Vascular Leakage

Young Jun Koh, Hak-Zoo Kim, Seong-Ik Hwang, +14

Cancer Cell

Tumor BiologyVascular LeakageAngiogenesisDouble Antiangiogenic ProteinMedicine +9