Alejandro Losada

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A

Kris M. White, Romel Rosales, Soner Yildiz et al. · Science · 2021 · 364 citations · Full text

Medicine, Infectious Diseases, Pharmacology +17

AplidinTM Induces Apoptosis in Human Cancer Cells via Glutathione Depletion and Sustained Activation of the Epidermal Growth Factor Receptor, Src, JNK, and p38 MAPK

Ana Cuadrado, Luis García‐Fernández, Laura González et al. · Journal of Biological Chemistry · 2002 · 155 citations · Full text

Life Sciences, Oncology, Pharmacology +17

Aplidin™ induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C δ

Luis García‐Fernández, Alejandro Losada, Victoria Alcaide et al. · Oncogene · 2002 · 134 citations

Life Sciences, Biochemistry, Cell Biology +17

Translation Elongation Factor eEF1A2 is a Novel Anticancer Target for the Marine Natural Product Plitidepsin

Alejandro Losada, María José Muñoz-Alonso, Carolina García et al. · Scientific Reports · 2016 · 95 citations · Full text

Medicine, Oncology, Pharmacology +14

Down-Regulation of Thyroid Transcription Factor-1 Gene Expression in Fetal Lung Hypoplasia Is Restored by Glucocorticoids*

Alejandro Losada, Juan A. Tovar, Hui Xia et al. · Endocrinology · 2000 · 52 citations · Full text

Life Sciences, Developmental Biology, Molecular Biology +16