Alejandro Losada

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A

Kris M. White, Romel Rosales, Soner Yildiz et al. · Science · 2021 · 356 citations · Full text

Medicine, Viral Pathogenesis, Immunology +14

AplidinTM Induces Apoptosis in Human Cancer Cells via Glutathione Depletion and Sustained Activation of the Epidermal Growth Factor Receptor, Src, JNK, and p38 MAPK

Ana Cuadrado, Luis García‐Fernández, Laura González et al. · Journal of Biological Chemistry · 2002 · 154 citations · Full text

Chemoprevention Strategy, Apoptosis, Cell Death +16

Aplidin™ induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C δ

Luis García‐Fernández, Alejandro Losada, Victoria Alcaide et al. · Oncogene · 2002 · 134 citations

Biochemistry, Mitochondrial Function, Apoptosis +8

Translation Elongation Factor eEF1A2 is a Novel Anticancer Target for the Marine Natural Product Plitidepsin

Alejandro Losada, María José Muñoz-Alonso, Carolina García et al. · Scientific Reports · 2016 · 94 citations · Full text

Cell Signaling, Medicine, Apoptosis +14

Down-Regulation of Thyroid Transcription Factor-1 Gene Expression in Fetal Lung Hypoplasia Is Restored by Glucocorticoids*

Alejandro Losada, Juan A. Tovar, Hui Xia et al. · Endocrinology · 2000 · 52 citations · Full text

Developmental Biology, Thyroid Transcription Factor, Cell Signaling +14