In Vivo Expression of Cyclooxygenase-1 in Activated Microglia and Macrophages During Neuroinflammation Visualized by PET with ¹¹C-Ketoprofen Methyl Ester

Miho Shukuri, Misato Takashima‐Hirano, Keiko Tokuda, +7

Journal of Nuclear Medicine

Establishment of In Vivo Brain Imaging Method in Conscious Mice

Hiroshi Mizuma, Miho Shukuri, Takuya Hayashi, +2

Journal of Nuclear Medicine

General Method for the ¹¹C‐Labeling of 2‐Arylpropionic Acids and Their Esters: Construction of a PET Tracer Library for a Study of Biological Events Involved in COXs Expression

Misato Takashima‐Hirano, Miho Shukuri, Tadayuki Takashima, +6

Chemistry - A European Journal

Combinatorial ChemistryBioorganic ChemistryMethyl EstersHeterocycle ChemistryGeneral Method +18

¹¹C-PK11195 PET for the In Vivo Evaluation of Neuroinflammation in the Rat Brain After Cortical Spreading Depression

Yilong Cui, Tadayuki Takashima, Misato Takashima‐Hirano, +7

Journal of Nuclear Medicine

Detection of Cyclooxygenase-1 in Activated Microglia During Amyloid Plaque Progression: PET Studies in Alzheimer’s Disease Model Mice

Miho Shukuri, Aya Mawatari, Masahiro Ohno, +4

Journal of Nuclear Medicine

Exploratory human PET study of the effectiveness of 11C-ketoprofen methyl ester, a potential biomarker of neuroinflammatory processes in Alzheimer's disease

Akihito Ohnishi, Michio Senda, Tomohiko Yamane, +15

Nuclear Medicine and Biology

Neurodegenerative DiseasesAlzheimer's DiseaseMedicineDementiaPotential Biomarker +8

Human whole-body biodistribution and dosimetry of a new PET tracer, [11C]ketoprofen methyl ester, for imagings of neuroinflammation

Akihito Ohnishi, Michio Senda, Tomohiko Yamane, +11

Nuclear Medicine and Biology

Positron Emission TomographyEngineeringMedicinePet-mriBiomedical Imaging +7

Assessment of radioligands for PET imaging of cyclooxygenase-2 in an ischemic neuronal injury model

Bin Ji, Katsushi Kumata, Hirotaka Onoe, +9

Brain Research

Positron Emission TomographyEngineeringPet ImagingNeurophysiologyPet-mri +9

Influence of Linker Molecules in Hexavalent RGD Peptides on Their Multivalent Interactions with Integrin α_vβ₃

Yuki Mizuno, Kohta Kimura, Satoru Onoe, +3

Journal of Medicinal Chemistry

Ex vivo imaging and analysis of ROS generation correlated with microglial activation in rat model with acute neuroinflammation induced by intrastriatal injection of LPS

Miho Shukuri, Miyu Uchino, Takafumi Sakamaki, +7

Biochemical and Biophysical Research Communications

Lipid PeroxidationReactive Oxygen SpeciesRat ModelOxidative StressNeuroinflammation +14