Jean‐Yves Le Questel

Systematic Investigation of Lipophilicity Modulation by Aliphatic Fluorination Motifs

Benjamin Jeffries, Zhong Wang, Hannah R. Felstead et al. · Journal of Medicinal Chemistry · 2020 · 154 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +17

Hydrogen-bond acceptor properties of nitriles: a combined crystallographic andab initio theoretical investigation

Jean‐Yves Le Questel, M. Berthelot, Christian Laurence · Journal of Physical Organic Chemistry · 2000 · 137 citations

Natural Sciences, Chemistry, Medicinal Chemistry +17

Halogen-bond geometry: a crystallographic database investigation of dihalogen complexes

Carole Ouvrard, Jean‐Yves Le Questel, M. Berthelot et al. · Acta Crystallographica Section B Structural Science · 2003 · 136 citations

Natural Sciences, Chemistry, Crystal Structure +16

Reducing the Lipophilicity of Perfluoroalkyl Groups by CF₂–F/CF₂–Me or CF₃/CH₃ Exchange

Benjamin Jeffries, Zhong Wang, Jérôme Graton et al. · Journal of Medicinal Chemistry · 2018 · 112 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

An Unexpected and Significantly Lower Hydrogen‐Bond‐Donating Capacity of Fluorohydrins Compared to Nonfluorinated Alcohols

Jérôme Graton, Zhong Wang, Anne‐Marie Brossard et al. · Angewandte Chemie International Edition · 2012 · 93 citations · Full text

Natural Sciences, Chemistry, Organic Chemistry +5