Identification of 9-cis-retinoic acid, 9,13-di-cis-retinoic acid, and 14-hydroxy-4,14-retro-retinol in human plasma after liver consumption

Thomas Arnhold, Georg Tzimas, W. Wittfoht, +2

Life Sciences

HepatologyOphthalmologyMedicineLiver Physiology9-Cis-retinoic Acid +8

Comparative Teratology and Transplacental Pharmacokinetics of All-trans-Retinoic Acid, 13-cis-Retinoic Acid, and Retinyl Palmitate Following Daily Administrations in Rats

Michael D. Collins, Georg Tzimas, Hans Hummler, +2

Toxicology and Applied Pharmacology

All-trans-retinoic AcidMedicineTransplacental PharmacokineticsComparative TeratologyDermatology +2

The percutaneous absorption of topically applied tretinoin and its effect on endogenous concentrations of tretinoin and its metabolites after single doses or long-term use

Louise Latriano, Georg Tzimas, Frankie A. Wong, +1

Journal of the American Academy of Dermatology

Long-term UseSingle DosesMedicineTopical DrugWound Healing +4

Endogenous Status of Retinoids and Their Cytosolic Binding Proteins in Limb Buds of Chick vs Mouse Embryos

William J. Scott, Rosemarie Walter, Georg Tzimas, +3

Developmental Biology

Developmental BiologyCell SpecializationGeneticsLimb BudsMorphogenesis +7

Human uterine leiomyomata express higher levels of peroxisome proliferator-activated receptor gamma, retinoid X receptor alpha, and all-trans retinoic acid than myometrium.

John C.M. Tsibris, Kathy B. Porter, Allahyar Jazayeri, +7

PubMed

Uterine LeiomyomataUterine FibroidsMedicineHormonal ReceptorUterine Receptivity +13

The Area under the Concentration–Time Curve of All-trans-Retinoic Acid Is the Most Suitable Pharmacokinetic Correlate to the Embryotoxicity of This Retinoid in the Rat

Georg Tzimas, Renate Thiel, Ibrahim Chahoud, +1

Toxicology and Applied Pharmacology

All-trans-retinoic AcidDevelopmental BiologyRetinaSuitable Pharmacokinetic CorrelateMedicine +4

The high sensitivity of the rabbit to the teratogenic effects of 13-cis-retinoic acid (isotretinoin) is a consequence of prolonged exposure of the embryo to 13-cis-retinoic acid and 13-cis-4-oxo-retinoic acid, and not of isomerization to all-trans-retinoic acid

Georg Tzimas, Heinrich Bürgin, Michael D. Collins, +2

Archives of Toxicology

All-trans-retinoic AcidXenotransplantationDevelopmental BiologyHigh SensitivityMedicine +5

Modulation of myb gene expression in sponges by retinoic acid.

Biesalski Hk, G Doepner, Georg Tzimas, +5

PubMed

Identification of 9,13-dicis-retinoic acid as a major plasma metabolite of 9-cis-retinoic acid and limited transfer of 9-cis-retinoic acid and 9,13-dicis-retinoic acid to the mouse and rat embryos.

Georg Tzimas, Jörn Oliver Sass, W. Wittfoht, +3

Drug Metabolism and Disposition

Antiepileptic drugs alter endogenous retinoid concentrations: A possible mechanism of teratogenesis of anticonvulsant therapy

Heinz Nau, Georg Tzimas, M. Mondry, +2

Life Sciences

Molecular NeuroscienceEndogenous Retinoid ConcentrationsOphthalmologyAntiepileptic DrugsMedicine +4