Olivier Léger

A recombinant humanized anti‐insulin‐like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti‐epidermal growth factor receptor therapy against human cancer xenografts

Liliane Goetsch, Alexandra Gonzalez, Olivier Léger et al. · International Journal of Cancer · 2004 · 217 citations · Full text

Humanization of a mouse antibody against human alpha-4 integrin: A potential therapeutic for the treatment of multiple sclerosis

Olivier Léger, Ted Yednock, Laura M. Tanner et al. · Human Antibodies · 1997 · 116 citations

Immunology, Immunologic Mechanism, Biological Therapy +21

Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis

Alain Vicari, Alain Schoepfer, Bertrand Meresse et al. · mAbs · 2017 · 43 citations · Full text

Immunodeficiencies, Immune Regulation, Immunology +18

The chondroitin sulfate proteoglycan NG2 is a tumour-specific antigen on the chemically induced rat chondrosarcoma HSN

Olivier Léger, Caroline Johnson‐Léger, Elizabeth B. Jackson et al. · International Journal of Cancer · 1994 · 32 citations

A single backmutation in the human kIV framework of a previously unsuccessfully humanized antibody restores the binding activity and increases the secretion in cos cells

José W. Saldanha, Andrew C.R. Martin, Olivier Léger · Molecular Immunology · 1999 · 21 citations

Signal Transduction, Single Backmutation, Immunology +8