JJ Birktoft

Antibody-probed conformational transitions in the protease domain of human factor IX upon calcium binding and zymogen activation: putative high-affinity Ca(2+)-binding site in the protease domain.

S Paul Bajaj, AK Sabharwal, J Gorka et al. · Proceedings of the National Academy of Sciences · 1992 · 79 citations · Full text

Immunology, Molecular Biology, Antigen Processing +21

The Aromatic Substrate Binding Site in Subtilisin BPN' and Its Resemblance to Chymotrypsin

J. Kraut, Jon D. Robertus, JJ Birktoft et al. · Cold Spring Harbor Symposia on Quantitative Biology · 1972 · 59 citations

Chemical Biology, Subtilisin Bpn′, Protein Chemistry +15

First epidermal growth factor-like domain of human blood coagulation factor IX is required for its activation by factor VIIa/tissue factor but not by factor XIa.

Degang Zhong, Kenneth J. Smith, JJ Birktoft et al. · Proceedings of the National Academy of Sciences · 1994 · 51 citations · Full text

Factor Ix, Immunology, Protein Expression +18

Experimental and theoretical evidence supporting the role of Gly363 in blood coagulation factor IXa (Gly193 in chymotrypsin) for proper activation of the proenzyme.

S Paul Bajaj, S G Spitzer, William J. Welsh et al. · Journal of Biological Chemistry · 1990 · 25 citations · Full text

Factor Ix, Immunology, Blood Cell +16

Hemophilia B caused by five different nondeletion mutations in the protease domain of factor IX

Michael Ludwig, AK Sabharwal, HH Brackmann et al. · Blood · 1992 · 24 citations · Full text