J P Witty

Expression and localization of matrix‐degrading metalloproteinases during colorectal tumorigenesis

Ken J. Newell, J P Witty, William H. Rodgers et al. · Molecular Carcinogenesis · 1994 · 253 citations

Medicine, Molecular Biology, Oncology +16

Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development.

J P Witty, James H. Wright, Lynn M. Matrisian · Molecular Biology of the Cell · 1995 · 193 citations · Full text

Life Sciences, Developmental Biology, Molecular Genetics +15

Modulation of matrilysin levels in colon carcinoma cell lines affects tumorigenicity in vivo.

J P Witty, Susan McDonnell, Ken J. Newell et al. · PubMed · 1994 · 188 citations

Medicine, Cell Biology, Oncology +16

Decreased tumor formation in 7,12-dimethylbenzanthracene-treated stromelysin-1 transgenic mice is associated with alterations in mammary epithelial cell apoptosis.

J P Witty, Tim Lempka, Robert J. Coffey et al. · PubMed · 1995 · 117 citations

Medicine, Cancer Biology, Oncology +11

Susceptibility of avian ovarian granulosa cells to apoptosis is dependent upon stage of follicle development and is related to endogenous levels of bcl-xlong gene expression.

A. L. Johnson, J. T. Bridgham, J P Witty et al. · Endocrinology · 1996 · 115 citations · Full text

Life Sciences, Cell Biology, Developmental Biology +16