Paul Kirkham

Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

Coen Wiegman, Charalambos Michaeloudes, Gulammehdi Haji et al. · Journal of Allergy and Clinical Immunology · 2015 · 446 citations · Full text

Life Sciences, Cell Biology, Pathobiology +17

Cigarette Smoke Alters Chromatin Remodeling and Induces Proinflammatory Genes in Rat Lungs

John A. Marwick, Paul Kirkham, Christopher S. Stevenson et al. · American Journal of Respiratory Cell and Molecular Biology · 2004 · 301 citations

Life Sciences, Molecular Biology, Toxicology +9

LPS induced inflammatory responses in human peripheral blood mononuclear cells is mediated through NOX4 and Giα dependent PI-3kinase signalling

Anta Ngkelo, Koremu Meja, Mike Yeadon et al. · Journal of Inflammation · 2012 · 254 citations · Full text

Life Sciences, Immunology, Pathobiology +17

Inhibition of PI3Kδ Restores Glucocorticoid Function in Smoking-induced Airway Inflammation in Mice

John A. Marwick, Gaetano Caramori, Christopher S. Stevenson et al. · American Journal of Respiratory and Critical Care Medicine · 2009 · 239 citations

Medicine, Cell Biology, Pharmacology +16

Curcumin Restores Corticosteroid Function in Monocytes Exposed to Oxidants by Maintaining HDAC2

Koremu Meja, R. Saravanan, David Adenuga et al. · American Journal of Respiratory Cell and Molecular Biology · 2008 · 207 citations · Full text

Medicine, Biochemistry, Pharmacology +17