1,3-Diaryl-4,5,6,7-tetrahydro-2<i>H</i>-isoindole Derivatives:  A New Series of Potent and Selective COX-2 Inhibitors in Which a Sulfonyl Group Is Not a Structural Requisite

Bernard Portevin, Charles Tordjman, Philippe Pastoureau, +2

Journal of Medicinal Chemistry

PharmacotherapyNew SeriesHeterocycle ChemistryCox-2 IsoenzymePharmaceutical Chemistry +17

Stereoselective synthesis of a new perhydroindole derivative of chiral iminodiacid, a potent inhibitor of angiotensin converting enzyme

M. Vincent, G. REMOND, Bernard Portevin, +2

Tetrahedron Letters

Medicinal ChemistryChiral IminodiacidBiochemistryNatural SciencesStereoselective Synthesis +6

New Prolyl Endopeptidase Inhibitors:  <i>In Vitro</i> and <i>in Vivo</i> Activities of Azabicyclo[2.2.2]octane, Azabicyclo[2.2.1]heptane, and Perhydroindole Derivatives

Bernard Portevin, Alain Benoist, G. REMOND, +4

Journal of Medicinal Chemistry

Inhibitory ActivityMedicinal ChemistryPharmaceutical ScienceBiochemistryMedicine +12

Configuration and preferential solid-state conformations of perindoprilat (S-9780). Comparison with the crystal structures of other ACE inhibitors and conclusions related to structure-activity relationships

Claudine Pascard, Jean Guilhem, M Lynch Vincent, +3

Journal of Medicinal Chemistry

Synthesis and CHK1 inhibitory potency of Hymenialdisine analogues

Jean‐Gilles Parmentier, Bernard Portevin, Roy M. Golsteyn, +4

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDerivative (Chemistry)MedicineChk1 Inhibitory PotencyPharmacology +2

Prolyl endopeptidase inhibitors: A new class of memory enhancing drugs

Guillaume De Nanteuil, Bernard Portevin, J. Lépagnol

Drugs of the Future

Medicinal ChemistryProlyl Endopeptidase InhibitorsMedicineNeuropharmacologyPharmacotherapy +4

Biguanide derivatives: agonist pharmacology at 5-hydroxytryptamine type 3 receptors in vitro.

Philippe Morain, Christine Abraham, Bernard Portevin, +1

Molecular Pharmacology

Synthesis and ACE inhibitory activity of the stereoisomers of perindopril (S 9490) and perindoprilate (S 9780).

M. Vincent, Bernard Marchand, G. REMOND, +7

PubMed

Organic ChemistryChemistryChemical BiologyPharmaceutical ChemistryAce Inhibitory Activity +15

Pharmacological profile of a novel series of NK1 antagonists. In vitro and in vivo potency of benzimidazolone derivatives

G. REMOND, Bernard Portevin, J Bonnet, +3

European Journal of Medicinal Chemistry

Molecular PharmacologyPharmacological StudyVivo PotencyImmunologyPharmacology +6

An expeditious multigram preparation of the marine protein kinase inhibitor debromohymenialdisine

Bernard Portevin, Roy M. Golsteyn, Alain St. Pierre, +1

Tetrahedron Letters

BiochemistryExpeditious Multigram PreparationMedicineReceptor Tyrosine KinasePharmacology +2