Patterns of somatic mutation in human cancer genomes

Christopher Greenman, Philip Stephens, Raffaella Smith, +60

Nature

Somatic MutationSomatic VariantGeneticsMedicineEpigenetics

Systematic identification of genomic markers of drug sensitivity in cancer cells

Mathew J. Garnett, Elena J. Edelman, Sonja J. Heidorn, +51

Nature

Systematic IdentificationGenomic MarkersEngineeringTumor HeterogeneityMedicine +10

A Landscape of Pharmacogenomic Interactions in Cancer

Francesco Iorio, Theo Knijnenburg, Daniël J. Vis, +36

Cell

Tumor BiologyOncologyTumor HeterogeneityMedicineDrug Response +11

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

Gillian L. Dalgliesh, Kyle Furge, Chris Greenman, +48

Nature

ChromatinCancer ResearchUrologyHistone Modifying GenesGenitourinary Cancer +9

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

Gijs van Haaften, Gillian L. Dalgliesh, Helen Davies, +59

Nature Genetics

Histone ModificationsChromatinSomatic VariantSomatic MutationsChromatin Remodeling +9

A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation

Patrick Tarpey, Raffaella Smith, Erin Pleasance, +74

Nature Genetics

ChromatinPsychiatryGenetic DisorderGeneticsPsychiatric Genetics +9

Somatic Mutations of the Protein Kinase Gene Family in Human Lung Cancer

Helen Davies, Chris Hunter, Raffaella Smith, +60

Cancer Research

X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment

Leanne M. Dibbens, Patrick Tarpey, Kim Hynes, +53

Nature Genetics

Neurodegenerative DiseasesMolecular NeuroscienceMendelian DisorderGenetic DisorderGenetics +9

Mutation analysis of 24 known cancer genes in the NCI-60 cell line set

Ogechi Ikediobi, Helen Davies, Graham R. Bignell, +45

Molecular Cancer Therapeutics

Effective drug combinations in breast, colon and pancreatic cancer cells

Patricia Jaaks, Elizabeth A. Coker, Daniël J. Vis, +25

Nature