Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s Disease

Juliette Le Douce, Marianne Maugard, Julien Veran, +33

Cell Metabolism

Neurodegenerative DiseasesNeurobiology Of DiseaseMolecular NeuroscienceAlzheimer's DiseaseAstrocytes Contributes +10

<scp>l</scp> -Serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons

Shigeki Furuya, Toshihide Tabata, Junya Mitoma, +7

Proceedings of the National Academy of Sciences

Astroglial expression of ceramide in Alzheimer's disease brains: A role during neuronal apoptosis

H. Satoi, Hidekazu Tomimoto, Ryo Ohtani, +8

Neuroscience

Alzheimer's DiseaseMedicineCell DeathNeurochemical BiomarkersNeuroprotection +7

3-Phosphoglycerate Dehydrogenase, a Key Enzyme forl-Serine Biosynthesis, Is Preferentially Expressed in the Radial Glia/Astrocyte Lineage and Olfactory Ensheathing Glia in the Mouse Brain

Miwako Yamasaki, Keiko Yamada, Shigeki Furuya, +3

Journal of Neuroscience

Glial BiologyNeural Stem CellCellular NeurobiologySynaptic SignalingSocial Sciences +23

3-Phosphoglycerate dehydrogenase, a key enzyme for l-serine biosynthesis, is preferentially expressed in the radial glia/astrocyte lineage and olfactory ensheathing glia in the mouse brain.

Miwako Yamasaki, Keiko Yamada, Shigeki Furuya, +3

PubMed

Neural Stem CellCellular NeurobiologySocial SciencesBiosynthesisL-serine Biosynthesis +19

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells

Saar Vandekeere, Charlotte Dubois, Joanna Kalucka, +20

Cell Metabolism

Serine SynthesisEndothelial CellsBiochemistryHeme DegradationHeme Signaling +8

Deficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schizophrenia

Keizo Takao, Katsunori Kobayashi, Hideo Hagihara, +24

Neuropsychopharmacology

Targeted Disruption of the Mouse 3-Phosphoglycerate Dehydrogenase Gene Causes Severe Neurodevelopmental Defects and Results in Embryonic Lethality

Kazuyuki Yoshida, Shigeki Furuya, Soh Osuka, +8

Journal of Biological Chemistry

Brain-specific Phgdh Deletion Reveals a Pivotal Role for l-Serine Biosynthesis in Controlling the Level of d-Serine, an N-methyl-d-aspartate Receptor Co-agonist, in Adult Brain

Jung Hoon Yang, Akira Wada, Kazuyuki Yoshida, +14

Journal of Biological Chemistry

NeurotransmitterBrain-specific Phgdh DeletionNeurochemical BiomarkersSocial SciencesL-serine Biosynthesis +17

Oxidative Stress Is Responsible for Deficient Survival and Dendritogenesis in Purkinje Neurons from Ataxia-Telangiectasia Mutated Mutant Mice

Philip Chen, Cheng Peng, John Luff, +5

Journal of Neuroscience

Knockout MouseNeurodegenerative DiseasesPurkinje NeuronsDevelopmental BiologyMedicine +11