Yasushi Nakatomi

A novel therapeutic approach combining human plasma‐derived Factors VIIa and X for haemophiliacs with inhibitors: evidence of a higher thrombin generation rate <i>in vitro</i> and more sustained haemostatic activity <i>in vivo</i> than obtained with Factor VIIa alone

Kazuhiko Tomokiyo, Yasushi Nakatomi, Tatsuya Araki et al. · Vox Sanguinis · 2003 · 58 citations

Medicine, Hematology, Pharmacology +15

Von Willebrand factor accelerates platelet adhesion and thrombus formation on a collagen surface in platelet-reduced blood under flow conditions

Kazuhiko Tomokiyo, Yuichi Kamikubo, Takako Hanada et al. · Blood · 2005 · 36 citations · Full text

Medicine, Cell Biology, Hematology +17

Combining FVIIa and FX into a mixture which imparts a unique thrombin generation potential to hemophilic plasma: an in vitro assessment of FVIIa/FX mixture as an alternative bypassing agent

Yasushi Nakatomi, Teruhisa Nakashima, Soutaro Gokudan et al. · Thrombosis Research · 2010 · 33 citations

Medicine, Hematology, Pharmacology +12

Stable complex formation between serine protease inhibitor and zymogen: coagulation factor X cleaves the Arg393–Ser394 bond in a reactive centre loop of antithrombin in the presence of heparin

Yasushi Nakatomi, Manami Tsuji, Soutaro Gokudan et al. · The Journal of Biochemistry · 2012 · 14 citations

Life Sciences, Biochemistry, Molecular Biology +17

Induction of Acquired Factor IX Inhibitors in Cynomolgus Monkey (Macaca Fascicularis): A New Primate Model of Hemophilia B

Kazuhiko Tomokiyo, Kaori Teshima, Yasushi Nakatomi et al. · Thrombosis Research · 2001 · 14 citations

Medicine, Hematology, Pharmacology +12