Yohei Shibuya

Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing

Salah Mahmoudi, Elena Mancini, Lucy Xu et al. · Nature · 2019 · 292 citations · Full text

Regenerative Medicine, Old Fibroblasts, Fibrosis +11

Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex

Yasuomi Urano, Hiroshi Watanabe, Stephanie R Murphy et al. · Proceedings of the National Academy of Sciences · 2008 · 121 citations · Full text

Treatment of a genetic brain disease by CNS-wide microglia replacement

Yohei Shibuya, Kevin K. Kumar, Marius Marc-Daniel Mader et al. · Science Translational Medicine · 2022 · 117 citations · Full text

Immunology, Cell Replacement Therapy, Microglia Replacement +21

Inhibiting ACAT1/SOAT1 in Microglia Stimulates Autophagy-Mediated Lysosomal Proteolysis and Increases Aβ1–42 Clearance

Yohei Shibuya, Catherine C.Y. Chang, Li‐Hao Huang et al. · Journal of Neuroscience · 2014 · 104 citations · Full text

Immunology, Neurochemical Biomarkers, Neuroinflammation +23

Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage

Yohei Shibuya, Zhaoyang Niu, Elena Y. Bryleva et al. · Neurobiology of Aging · 2015 · 93 citations

Cell Autophagy, Mitophagy, Triple Transgenic Alzheimer +10