Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

John C. Pui, David Allman, Lanwei Xu, +8

Immunity

Essential Roles for Ankyrin Repeat and Transactivation Domains in Induction of T-Cell Leukemia by Notch1

Jon C. Aster, Lanwei Xu, Fredrick G. Karnell, +3

Molecular and Cellular Biology

Hematological MalignancySignal TransductionAnkyrin RepeatCell RegulationNotch Receptor +13

Deltex1 Redirects Lymphoid Progenitors to the B Cell Lineage by Antagonizing Notch1

David J. Izon, Jon C. Aster, Yiping He, +8

Immunity

Lymphoid NeoplasiaCell LineageLineage PlasticityDevelopmental BiologyAntagonizing Notch1 +10

Tonic B cell antigen receptor signals supply an NF-κB substrate for prosurvival BLyS signaling

Jason Stadanlick, Mary Kaileh, Fredrick G. Karnell, +9

Nature Immunology

InflammationSignal TransductionImmune Cell DevelopmentHumoral ResponseImmune Regulation +13

Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies

Patrick A. Zweidler‐McKay, Yiping He, Lanwei Xu, +6

Blood

Notch1 Regulates Maturation of CD4+ and CD8+ Thymocytes by Modulating TCR Signal Strength

David J. Izon, Jennifer A. Punt, Lanwei Xu, +7

Immunity

Notch1 Regulates MaturationSignal TransductionLymphocyte DevelopmentImmune Cell DevelopmentImmunology +7

Separation of Notch1 Promoted Lineage Commitment and Expansion/Transformation in Developing T Cells

David Allman, Fredrick G. Karnell, Jennifer A. Punt, +7

The Journal of Experimental Medicine

The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia–like disease by bcr/abl

Yiping He, Jason A. Wertheim, Lanwei Xu, +5

Blood

P62dok, a Negative Regulator of Ras and Mitogen-Activated Protein Kinase (Mapk) Activity, Opposes Leukemogenesis by P210bcr-abl

Antonio Di Cristofano, Masaru Niki, Mingming Zhao, +5

The Journal of Experimental Medicine

Mycophenolic Acid Differentially Impacts B Cell Function Depending on the Stage of Differentiation

Jodi L. Karnell, Fredrick G. Karnell, Geoffrey L. Stephens, +10

The Journal of Immunology

ImmunologyImmune RegulationImmunologic MechanismCell CycleCellular Physiology +18