Exomic Sequencing Identifies <i>PALB2</i> as a Pancreatic Cancer Susceptibility Gene

Siân Jones, Ralph H. Hruban, Mihoko Kamiyama, +16

Science

EngineeringPalb2 ProteinGeneticsGenetic EpidemiologyPathology +15

Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds

Alison P. Klein, Kieran Brune, Gloria M. Petersen, +8

Cancer Research

Screening for Early Pancreatic Neoplasia in High-Risk Individuals: A Prospective Controlled Study

Marcia Irene Canto, Michael Goggins, Ralph H. Hruban, +12

Clinical Gastroenterology and Hepatology

Pancreatic CancerEarly Pancreatic NeoplasiaCancer ScreeningMedicineGastroenterology +5

Screening for pancreatic neoplasia in high-risk individuals: an EUS-based approach

Marcia Irene Canto, Michael Goggins, Charles J. Yeo, +10

Clinical Gastroenterology and Hepatology

Pancreatic CancerPancreatic Fluid CollectionCancer ScreeningMedicineInterventional Endoscopic Ultrasound +8

Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%.

Kathleen M. Murphy, Kieran Brune, Constance A. Griffin, +5

PubMed

Tumor BiologyOncologyCandidate Genes Map2k4Pancreatic CancerSomatic Variant +13

Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer.

Kieran Brune, Tadayoshi Abe, Marcia Irene Canto, +10

PubMed

Surgical OncologyStrong Family HistoryGastroenterologyPathologyLobular Atrophy +15

Increased risk of incident pancreatic cancer among first-degree relatives of patients with familial pancreatic cancer.

Anne C. Tersmette, Gloria M. Petersen, G.J.A. Offerhaus, +9

PubMed

Family MedicineFirst-degree RelativesPc RiskEpidemiology Of CancerGenetic Epidemiology +15

The Prevalence of BRCA2 Mutations in Familial Pancreatic Cancer

Fergus J. Couch, Michele R. Johnson, Kari G. Rabe, +8

Cancer Epidemiology Biomarkers & Prevention

PancPRO: Risk Assessment for Individuals With a Family History of Pancreatic Cancer

Wenyi Wang, Sining Chen, Kieran Brune, +3

Journal of Clinical Oncology

Methylation of cyclin D2 is observed frequently in pancreatic cancer but is also an age-related phenomenon in gastrointestinal tissues.

Hiroyuki Matsubayashi, Norihiro Sato, Noriyoshi Fukushima, +6

PubMed