MS ^E with mass defect filtering for <i>in vitro</i> and <i>in vivo</i> metabolite identification

Kevin P. Bateman, José Castro‐Perez, Mark Wrona, +4

Rapid Communications in Mass Spectrometry

‘All‐in‐One’ analysis for metabolite identification using liquid chromatography/hybrid quadrupole time‐of‐flight mass spectrometry with collision energy switching

Mark Wrona, Timo Mauriala, Kevin P. Bateman, +2

Rapid Communications in Mass Spectrometry

Biological Mass SpectrometryMetabolomic ProfilingDrug Discovery EnvironmentGas ChromatographyBioanalysis +17

Discovery of 4-{1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain

John Colucci, Michael J. Boyd, Carl Berthelette, +14

Bioorganic & Medicinal Chemistry Letters

InflammationMedicinal ChemistryAnti-inflammatoryHealth SciencesInflammatory Pain +11

The Discovery of 4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic Acid (MK-2894), A Potent and Selective Prostaglandin E₂Subtype 4 Receptor Antagonist

Marc Blouin, Yongxin Han, Jason D. Burch, +16

Journal of Medicinal Chemistry

Solution NMR Structure and X-ray Absorption Analysis of the C-Terminal Zinc-Binding Domain of the SecA ATPase

Brian R. Dempsey, Mark Wrona, Jana M. Moulin, +5

Biochemistry

Chemical Profiling of Ginseng Species and Ginseng Herbal Products Using UPLC/QTOF-MS

Jimmy Yuk, Dhavalkumar Narendrabhai Patel, Giorgis Isaac, +4

Journal of the Brazilian Chemical Society

Novel Interconnections in Lipid Metabolism Revealed by Overexpression of Sphingomyelin Synthase-1

Gergana M. Deevska, P. Patrick Dotson, Alexander Karakashian, +5

Journal of Biological Chemistry

A novel series of potent and selective EP4 receptor ligands: Facile modulation of agonism and antagonism

Michael J. Boyd, Carl Berthelette, Jean-François Chiasson, +11

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologySignal TransductionNovel SeriesFunctional SelectivityMedicine +9

Structure–activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP4 receptor

Jason D. Burch, Michel Belley, Réjean Fortin, +15

Bioorganic & Medicinal Chemistry Letters

Pharmaceutical ScienceQuinoline AcylsulfonamidesPharmacological StudyBiochemistryMedicine +6

Metabolic Profiling of Hoodia, Chamomile, Terminalia Species and Evaluation of Commercial Preparations Using Ultrahigh-Performance Liquid Chromatography Quadrupole-Time-of-Flight Mass Spectrometry

Bharathi Avula, Yan‐Hong Wang, Giorgis Isaac, +4

Planta Medica