Identification of Novel T1D Risk Loci and Their Association With Age and Islet Function at Diagnosis in Autoantibody-Positive T1D Individuals: Based on a Two-Stage Genome-Wide Association Study

Meng Zhu, Kuanfeng Xu, Yang Chen, +50

Diabetes Care

Injury factors alter miRNAs profiles of exosomes derived from islets and circulation

Qi Fu, Hemin Jiang, Zibin Wang, +6

Aging

EngineeringIslets DamageImmunologyPathologyExtracellular Microvesicles +22

Hepatocytes derived extracellular vesicles from high-fat diet induced obese mice modulate genes expression and proliferation of islet β cells

Qi Fu, Yue Li, Hemin Jiang, +6

Biochemical and Biophysical Research Communications

High-fat DietFatty Liver DiseaseInsulin SignalingObesityInflammation +14

Circulating microRNA‑135a‑3p in serum extracellular vesicles as a potential biological marker of non‑alcoholic fatty liver disease

Hemin Jiang, Ziyang Shen, Yuwei Liu, +6

Molecular Medicine Reports

Single-cell RNA sequencing combined with single-cell proteomics identifies the metabolic adaptation of islet cell subpopulations to high-fat diet in mice

Qi Fu, Hemin Jiang, Hui Lv, +11

Diabetologia

ObesityMetabolic SyndromeSingle-cell ProteomicsSystems BiologySingle Cell Sequencing +13

Aberrant activation of Notch-1 signaling inhibits podocyte restoration after islet transplantation in a rat model of diabetic nephropathy

Yunqiang He, Mei Zhang, Ying Wu, +7

Cell Death and Disease

Interferon‐α promotes MHC I antigen presentation of islet β cells through STAT1‐IRF7 pathway in type 1 diabetes

Hemin Jiang, Yue Li, Min Shen, +9

Immunology

ImmunologyImmune RegulationImmunologic MechanismCd4 T Cell ResponsesImmune System +22

MicroRNA-127 inhibits cell proliferation via targeting Kif3b in pancreatic β cells

Ziyang Shen, Hemin Jiang, Hsiang‐Ting Hsu, +4

Aging

Temporal metabolic and transcriptomic characteristics crossing islets and liver reveal dynamic pathophysiology in diet-induced diabetes

Rui Gao, Qi Fu, Hemin Jiang, +8

iScience

Follicular Regulatory T Cells Are Associated With β-Cell Autoimmunity and the Development of Type 1 Diabetes

Xinyu Xu, Min Shen, Ruiling Zhao, +7

The Journal of Clinical Endocrinology & Metabolism