Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets

Jing Hua Zhao, David Stacey, Niclas Eriksson, +43

Nature Immunology

Chronic Inflammatory DiseasesImmunologyGenetic EpidemiologyImmune RegulationPathology +24

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

Richard J. Mills, Drew M. Titmarsh, Xaver Koenig, +20

Proceedings of the National Academy of Sciences

Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway

Richard J. Mills, Benjamin L. Parker, Gregory A. Quaife-Ryan, +15

Cell stem cell

BiochemistryMedicineMevalonate PathwayPharmacotherapyDrug Screening +5

An integrative systems genetic analysis of mammalian lipid metabolism

Benjamin L. Parker, Anna C. Calkin, Marcus Seldin, +24

Nature

Lipid AnalysisMammalian Lipid MetabolismLipid MetabolismGeneticsMetabolism +4

Vascular cells improve functionality of human cardiac organoids

Holly K. Voges, Simon R. Foster, Liam Reynolds, +33

Cell Reports

Organoid MaturationCardiac Progenitor CellsCardiovascular FunctionCellular PhysiologyRegenerative Medicine +15

Personalized phosphoproteomics identifies functional signaling

Elise J. Needham, Janne R. Hingst, Benjamin L. Parker, +14

Nature Biotechnology

Signal TransductionSignaling PathwayPhysiologyBiological FunctionCellular Biochemistry +4

Phosphoproteomics reveals conserved exercise‐stimulated signaling and AMPK regulation of store‐operated calcium entry

Marin E. Nelson, Benjamin L. Parker, James G. Burchfield, +14

The EMBO Journal

Muscle PhysiologyMuscle FunctionKinesiologyMolecular PhysiologySignal Transduction +13

Development of a human skeletal micro muscle platform with pacing capabilities

Richard J. Mills, Benjamin L. Parker, Pauline Monnot, +7

Biomaterials

MechanobiologyMuscle FunctionEngineeringSkeletal MuscleMechanical Engineering +6

Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance

Daniel J. Fazakerley, Julian van Gerwen, Kristen C. Cooke, +13

Nature Communications

Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells

Ariadna Recasens, Sean J. Humphrey, M. A. Ellis, +11

Cell Death Discovery