A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties

Kevin Dooley, Russell E. McConnell, Ke Xu, +25

Molecular Therapy

Exosome-mediated genetic reprogramming of tumor-associated macrophages by exoASO-STAT6 leads to potent monotherapy antitumor activity

Sushrut Kamerkar, Charan Leng, Olga Burenkova, +15

Science Advances

ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance

Su Chul Jang, Kyriakos D. Economides, Raymond J. Moniz, +20

Communications Biology

Co-delivery of a growth factor and a tissue-protective molecule using elastin biopolymers accelerates wound healing in diabetic mice

Julie Devallière, Kevin Dooley, Yong Hu, +3

Biomaterials

Tissue EngineeringRegenerative MedicineEngineeringElastin BiopolymersGrowth Factor +11

Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12

Nuruddeen D. Lewis, Chang Ling Sia, Katherine Kirwin, +17

Molecular Cancer Therapeutics

Improving functional re-endothelialization of acellular liver scaffold using REDV cell-binding domain

Julie Devallière, Yibin Chen, Kevin Dooley, +2

Acta Biomaterialia

AngiogenesisHepatologyMedicineLiver PhysiologyRedv Cell-binding Domain +12

Rapid Development of New Protein Biosensors Utilizing Peptides Obtained via Phage Display

Jun Wu, Jong Pil Park, Kevin Dooley, +3

PLoS ONE

A dual enzyme electrochemical assay for the detection of organophosphorus compounds using organophosphorus hydrolase and horseradish peroxidase

Kevin Dooley, Donald M. Cropek, Alan C. West, +1

Sensors and Actuators B Chemical

Horseradish PeroxidaseEngineeringBiochemistryBioelectrochemistryOrganophosphorus Hydrolase +10

Engineering of an Environmentally Responsive Beta Roll Peptide for Use As a Calcium-Dependent Cross-Linking Domain for Peptide Hydrogel Formation

Kevin Dooley, Yang Hee Kim, Hoang D. Lu, +2

Biomacromolecules

Tissue EngineeringEngineeringBiomimetic MaterialsPeptide EngineeringBiomaterials Design +21

In vivo tracking of [89Zr]Zr-labeled engineered extracellular vesicles by PET reveals organ-specific biodistribution based upon the route of administration

Shil Patel, Karl Schmidt, Mohammed Farhoud, +7

Nuclear Medicine and Biology