Melissa A. Kachura

CpG-containing immunostimulatory DNA sequences elicit TNF-α–dependent toxicity in rodents but not in humans

John D. Campbell, Yan Cho, Martyn Foster et al. · Journal of Clinical Investigation · 2009 · 72 citations · Full text

Life Sciences, Immunology, Toxicology +14

Low-dose self-amplifying mRNA COVID-19 vaccine drives strong protective immunity in non-human primates against SARS-CoV-2 infection

Amy Rappaport, Sue‐Jean Hong, Ciaran D. Scallan et al. · Nature Communications · 2022 · 57 citations · Full text

Veterinary Medicine, Immunology, Infectious Diseases +17

GRT-R910: a self-amplifying mRNA SARS-CoV-2 vaccine boosts immunity for ≥6 months in previously-vaccinated older adults

Christine D. Palmer, Ciaran D. Scallan, Lauren D. Kraemer Tardif et al. · Nature Communications · 2023 · 39 citations · Full text

Veterinary Medicine, Immunology, Infectious Diseases +17

Preclinical development of the TLR9 agonist DV281 as an inhaled aerosolized immunotherapeutic for lung cancer: Pharmacological profile in mice, non-human primates, and human primary cells

Sariah Kell, Melissa A. Kachura, Alex Renn et al. · International Immunopharmacology · 2018 · 28 citations

Medicine, Immunology, Pharmacology +17

A CpG-Ficoll Nanoparticle Adjuvant for Anthrax Protective Antigen Enhances Immunogenicity and Provides Single-Immunization Protection against Inhaled Anthrax in Monkeys

Melissa A. Kachura, Colin L. Hickle, Sariah Kell et al. · The Journal of Immunology · 2015 · 27 citations · Full text

Pharmacy, Biotechnology, Immunology +17