Microglia-mediated degradation of perineuronal nets promotes pain

Shannon Tansley, Ning Gu, Alba Ureña Guzmán, +21

Science

Projection NeuronsPain SyndromeSpinal Cord InjuryHealth SciencesPain Medicine +12

Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain

Shannon Tansley, Sonali Uttam, Alba Ureña Guzmán, +20

Nature Communications

Translational profiling of dorsal root ganglia and spinal cord in a mouse model of neuropathic pain

Sonali Uttam, Calvin Wong, Inês S. Amorim, +7

Neurobiology of Pain

The gut microbiota promotes pain in fibromyalgia

Weihua Cai, May Haddad, R. Haddad, +37

Neuron

mTORC2 mediates structural plasticity in distal nociceptive endings that contributes to pain hypersensitivity following inflammation

Calvin Wong, Omer Barkai, Feng Wang, +16

Journal of Clinical Investigation

Pain MedicineImmunologyNeuropathic PainMolecular PainStructural Plasticity +16

Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome

Mehdi Hooshmandi, Vijendra Sharma, Carolina Thörn Pérez, +28

Neuron

Neurodevelopmental DisordersFragile X SyndromePsychiatrySyndromic AutismExcitatory Neuron-specific Suppression +11

Parvalbumin interneuron loss mediates repeated anesthesia-induced memory deficits in mice

Patricia Roque, Carolina Thörn Pérez, Mehdi Hooshmandi, +22

Journal of Clinical Investigation

Anesthetic MechanismBrain ScienceSocial SciencesMemoryParvalbumin Neurons +16

4E-BP1–dependent translation in nociceptors controls mechanical hypersensitivity via TRIM32/type I interferon signaling

Calvin Wong, Diana Tavares‐Ferreira, Carolina Thörn Pérez, +11

Science Advances

Targeting C1q prevents microglia-mediated synaptic removal in neuropathic pain

Noosha Yousefpour, Shannon Tansley, Samantha Locke, +24

Nature Communications

4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors

Mehdi Hooshmandi, Vinh Tai Truong, Eviatar Fields, +15

Cell Reports