Topors Functions as an E3 Ubiquitin Ligase with Specific E2 Enzymes and Ubiquitinates p53

Rajeev Rajendra, Diptee Malegaonkar, Pooja Pungaliya, +7

Journal of Biological Chemistry

Elevated Expression of ISG15 in Tumor Cells Interferes with the Ubiquitin/26S Proteasome Pathway

Shyamal D. Desai, Arthur L. Haas, Laurence M. Wood, +6

Cancer Research

ImmunologyIsg15 ExpressionTumor CellsUbiquitin/26s Proteasome PathwayCancer Biology +16

Activation of Raf-1 and mitogen-activated protein kinases during monocytic differentiation of human myeloid leukemia cells.

Surender Kharbanda, Ahamed Saleem, Yutaka Emoto, +3

Journal of Biological Chemistry

Mitogen-activated Protein KinasesMixed-phenotype Acute LeukemiaImmunologyTumor BiologyMyeloid Neoplasia +14

Ionizing radiation induces rapid tyrosine phosphorylation of p34cdc2.

Surender Kharbanda, Ahamed Saleem, Rupak Datta, +3

PubMed

Radiation ChemistryRadiation OncologyIncreased Tyrosine PhosphorylationSignal TransductionCell Regulation +12

Ionizing Radiation Stimulates a Grb2-mediated Association of the Stress-activated Protein Kinase with Phosphatidylinositol 3-Kinase

Surender Kharbanda, Ahamed Saleem, Timothy D. Shafman, +8

Journal of Biological Chemistry

Differential effects of the breast cancer resistance protein on the cellular accumulation and cytotoxicity of 9-aminocamptothecin and 9-nitrocamptothecin.

Rajeev Rajendra, Murugesan Gounder, Ahamed Saleem, +5

PubMed

Other Cpt AnaloguesCellular AccumulationDifferential EffectsBreast OncologyNew Cpt Analogues +12

Stimulation of human monocytes with macrophage colony-stimulating factor induces a Grb2-mediated association of the focal adhesion kinase pp125FAK and dynamin.

Surender Kharbanda, Ahamed Saleem, Zhaohu Yuan, +3

Proceedings of the National Academy of Sciences

Cell AdhesionImmunologyCellular PhysiologyInflammationSignaling Pathway +15

Defective induction of stress-activated protein kinase activity in ataxia-telangiectasia cells exposed to ionizing radiation.

Timothy D. Shafman, Ahamed Saleem, John Kyriakis, +3

PubMed

Defective InductionRadiation EffectImmunologyRadiation ExposureRadiation Biology +15

TOPORS Functions As A SUMO-1 E3 Ligase for Chromatin-Modifying Proteins

Pooja Pungaliya, Diptee Kulkarni, Hyejin Park, +5

Journal of Proteome Research

Nuclear signaling induced by ionizing radiation involves colocalization of the activated p56/p53lyn tyrosine kinase with p34cdc2.

Surender Kharbanda, Ahamed Saleem, Zhi-Min Yuan, +4

PubMed

Radiation OncologyConfocal Microscopy StudiesSignal TransductionNuclear LynCell Regulation +13