Mechanisms and therapeutic implications of hypermutation in gliomas

Mehdi Touat, Yvonne Y. Li, Adam N. Boynton, +75

Nature

Neuro-oncologyMedicineTherapeutic ImplicationsHigh-grade GliomasCell Biology +3

Identification, validation and biological characterisation of novel glioblastoma tumour microenvironment subtypes: implications for precision immunotherapy

Kirsten A. White, Kate Connor, Maxime Meylan, +42

Annals of Oncology

Preclinical Efficacy of the MDM2 Inhibitor RG7112 in <i>MDM2</i> -Amplified and <i>TP53</i> Wild-type Glioblastomas

Maïté Verreault, Charlotte Schmitt, Lauriane Goldwirt, +16

Clinical Cancer Research

SLIT2/ROBO signaling in tumor-associated microglia and macrophages drives glioblastoma immunosuppression and vascular dysmorphia

Luiz Henrique Geraldo, Yunling Xu, Laurent Jacob, +22

Journal of Clinical Investigation

ImmunologyCancer BiologyGliomaTumor BiologyNeuroinflammation +19

Temporary blood–brain barrier disruption by low intensity pulsed ultrasound increases carboplatin delivery and efficacy in preclinical models of glioblastoma

Antonin Dréan, Nolwenn Lemaire, Guillaume Bouchoux, +13

Journal of Neuro-Oncology

Neuro-oncologyFocused UltrasoundEngineeringPreclinical ModelsMedicine +10

Polo-Like Kinase 1 Inhibition Kills Glioblastoma Multiforme Brain Tumor Cells in Part Through Loss of SOX2 and Delays Tumor Progression in Mice

Cathy Lee, Abbas Fotovati, Joanna Triscott, +13

Stem Cells

Cell DeathPathologyHigh-grade GliomasCancer BiologyGlioma +17

A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma

Elias A. El-Habr, Luiz Gustavo Dubois, Fanny Burel‐Vandenbos, +27

Acta Neuropathologica

Neuro-oncologyGaba MetabolismGhb ProductionCell RegulationGlioma +9

A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas

Shai Rosenberg, Iva Simeonova, Franck Bielle, +23

Nature Communications

Suppression of VEGF secretion and changes in glioblastoma multiforme microenvironment by inhibition of Integrin-linked kinase (ILK)

Lincoln Edwards, Janet Woo, Lynsey A. Huxham, +15

Molecular Cancer Therapeutics

Vascular normalization in orthotopic glioblastoma following intravenous treatment with lipid-based nanoparticulate formulations of irinotecan (Irinophore C™), doxorubicin (Caelyx®) or vincristine

Maïté Verreault, Dita Strutt, Dana Masin, +6

BMC Cancer