Benjamin Challis

Rare variant contribution to human disease in 281,104 UK Biobank exomes

Quanli Wang, Ryan S. Dhindsa, Keren Carss et al. · Nature · 2021 · 604 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY _3-36

Benjamin Challis, Anthony P. Coll, Giles S.H. Yeo et al. · Proceedings of the National Academy of Sciences · 2004 · 374 citations · Full text

Life Sciences, Endocrinology, Physiology +17

A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism

Benjamin Challis · Human Molecular Genetics · 2002 · 291 citations · Full text

Life Sciences, Genetics, Molecular Genetics +16

Acute effects of PYY3–36 on food intake and hypothalamic neuropeptide expression in the mouse

Benjamin Challis, Scarlett B. Pinnock, Anthony P. Coll et al. · Biochemical and Biophysical Research Communications · 2003 · 241 citations

Medicine, Neurobiology, Neuroscience +17

Heterozygosity for a <i>POMC</i>-Null Mutation and Increased Obesity Risk in Humans

I. Sadaf Farooqi, Stenvert L. S. Drop, Agnes Clements et al. · Diabetes · 2006 · 233 citations

Life Sciences, Genetics, Molecular Genetics +17