Simultaneous changes in central and peripheral components of the hypothalamus-pituitary-thyroid axis in lipopolysaccharide-induced acute illness in mice

Anita Boelen, Joan Kwakkel, DC Thijssen-Timmer, +3

Journal of Endocrinology

ImmunologyLipopolysaccharide-induced Acute IllnessInflammationNeuroendocrine MechanismHypothalamic Peptide +15

Induction of Type 3 Deiodinase Activity in Inflammatory Cells of Mice with Chronic Local Inflammation

Anita Boelen, Joan Kwakkel, Anneke Alkemade, +5

Endocrinology

ImmunologyOxidative StressInflammationSkeletal MuscleHepatotoxicity +19

Both immunisation with a formalin-inactivated respiratory syncytial virus (RSV) vaccine and a mock antigen vaccine induce severe lung pathology and a Th2 cytokine profile in RSV-challenged mice

Anita Boelen, Arno C. Andeweg, Joan Kwakkel, +4

Vaccine

VaccinationMucosal VaccinationRespiratory Virus ImmunityVaccine DevelopmentRsv-challenged Mice +6

Hypothalamic Neuropeptide Y (NPY) Controls Hepatic VLDL-Triglyceride Secretion in Rats via the Sympathetic Nervous System

Eveline Bruinstroop, Lei Pei, Mariëtte T. Ackermans, +6

Diabetes

Hypothalamic CircuitsGastrointestinal Peptide HormoneMetabolic SyndromeSympathetic Nervous SystemExcessive Secretion +17

A Novel Role for the Thyroid Hormone-Activating Enzyme Type 2 Deiodinase in the Inflammatory Response of Macrophages

Joan Kwakkel, Olga V. Surovtseva, Emmely M. de Vries, +3

Endocrinology

ImmunologyImmune RegulationNovel Inflammatory ResponseInnate ImmunityImmune System +21

Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging

W. Edward Visser, Cíntia R. Bombardieri, Chantal Zevenbergen, +24

PLoS ONE

Dna DamageAgingBiogerontologyOxidative StressTranscriptional Regulation +20

Type 3 Deiodinase Is Highly Expressed in Infiltrating Neutrophilic Granulocytes in Response to Acute Bacterial Infection

Anita Boelen, Jeffrey Boorsma, Joan Kwakkel, +5

Thyroid

Chronic local inflammation in mice results in decreased TRH and type 3 deiodinase mRNA expression in the hypothalamic paraventricular nucleus independently of diminished food intake

Anita Boelen, Joan Kwakkel, Wilmar M. Wiersinga, +1

Journal of Endocrinology

ImmunologyFood IntakeTurpentine AdministrationDecreased TrhHypothalamic Circuits +20

Impaired Bacterial Clearance in Type 3 Deiodinase-Deficient Mice Infected with Streptococcus pneumoniae

Anita Boelen, Joan Kwakkel, Catharina W. Wieland, +3

Endocrinology

Lung InflammationKlebsiella PneumoniaeImmunologyInnate Immune SystemInnate Immunity +19

Differential involvement of nuclear factor-κB and activator protein-1 pathways in the interleukin-1β-mediated decrease of deiodinase type 1 and thyroid hormone receptor β1 mRNA

Joan Kwakkel, W M Wiersinga, Anita Boelen

Journal of Endocrinology

Il-1beta StimulationImmunologyPathologyCell DeathDeiodinase Type 1 +17