Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide

Dale L. Boger, Haruhiko Sato, Aaron E. Lerner, +7

Proceedings of the National Academy of Sciences

Discovery of a Potent, Selective, and Efficacious Class of Reversible α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Effective as Analgesics

Dale L. Boger, Hiroshi Miyauchi, Wu Du, +10

Journal of Medicinal Chemistry

Pharmaceutical ScienceDrug TargetPain MedicineMolecular PainPharmacotherapy +19

Structural basis for macrolactonization by the pikromycin thioesterase

David L. Akey, Jeffrey D. Kittendorf, J. Giraldes, +3

Nature Chemical Biology

BiotransformationBiochemistryNatural SciencesPikromycin ThioesteraseChemical Biology +1

Behavioral Evidence for the Interaction of Oleamide with Multiple Neurotransmitter Systems

I. M. Fedorova, Akihiro Hashimoto, Robert Fecik, +5

Journal of Pharmacology and Experimental Therapeutics

Fatty acid amide hydrolase substrate specificity

Dale L. Boger, Robert Fecik, Jean E. Patterson, +3

Bioorganic & Medicinal Chemistry Letters

Enzyme SpecificityBiochemistryHydrolase Substrate Specificity

Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels

J. Giraldes, David L. Akey, Jeffrey D. Kittendorf, +3

Nature Chemical Biology

Synthetic MacromoleculePolymer ChemistryPolyketide MacrolactonizationEngineeringPolymer Science +8

Chemoenzymatic Synthesis of the Polyketide Macrolactone 10-Deoxymethynolide

Courtney C. Aldrich, Lakshmanan Venkatraman, David H. Sherman, +1

Journal of the American Chemical Society

Bioorganic ChemistryEngineeringOrganic ChemistryChemistryChemical Biology +16

Biochemical Investigation of Pikromycin Biosynthesis Employing Native Penta- and Hexaketide Chain Elongation Intermediates

Courtney C. Aldrich, Brian J. Beck, Robert Fecik, +1

Journal of the American Chemical Society

Combinatorial ChemistryAcyl Chain ReleaseEngineeringChemical BiologyBiosynthesis +14

Total Synthesis and Biological Evaluation of Tubulysin U, Tubulysin V, and Their Analogues

Ranganathan Balasubramanian, Bhooma Raghavan, Adrian Begaye, +2

Journal of Medicinal Chemistry

Medicinal ChemistryBioorganic ChemistryBiochemistryTubulysin VNatural Sciences +12

Iterative Chain Elongation by a Pikromycin Monomodular Polyketide Synthase

Brian J. Beck, Courtney C. Aldrich, Robert Fecik, +2

Journal of the American Chemical Society