Gary McCort

Discovery of (2<i>S</i>)-8-[(3<i>R</i>)-3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2<i>H</i>-pyrimido[1,2-<i>a</i>]pyrimidin-6-one: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors

Benoit Pasquier, Youssef El‐Ahmad, Bruno Filoche-Rommé et al. · Journal of Medicinal Chemistry · 2014 · 92 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3<i>S</i>)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7<i>H</i>-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer

Youssef El‐Ahmad, Michel Tabart, Frank Halley et al. · Journal of Medicinal Chemistry · 2019 · 81 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models

Maysoun Shomali, Jane Cheng, Fangxian Sun et al. · Molecular Cancer Therapeutics · 2020 · 67 citations · Full text

Medicine, Oncology, Pharmacology +15

Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors

Bodo Scheiper, Hans Matter, Henning Steinhagen et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 47 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Structure-based design and optimization of potent renin inhibitors on 5- or 7-azaindole-scaffolds

Hans Matter, Bodo Scheiper, Henning Steinhagen et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 29 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13