Dennis V. Nazareno

Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. IV. Discovery of 1-[(4,6-Dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-{2-methoxy-1(<i>R</i>)-4-(trifluoromethyl)phenyl}ethyl-3(<i>S</i>)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a Potent, Highly Selective, and Orally Bioavailable CCR5 Antagonist

Jayaram R. Tagat, Stuart W. McCombie, Dennis V. Nazareno et al. · Journal of Medicinal Chemistry · 2004 · 136 citations · Full text

Excellent Receptor Selectivity, Immunology, Hiv-1 Inhibitors +19

Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. II. Discovery of 1-[(2,4-Dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(<i>S</i>)-methyl-4-[1(<i>S</i>)-[4-(trifluoro- methyl)phenyl]ethyl]-1-piperazinyl]- piperidine <i>N</i>1-Oxide (Sch-350634), an Orally Bioavailable, Potent CCR5 Antagonist

Jayaram R. Tagat, Ruo W. Steensma, Stuart W. McCombie et al. · Journal of Medicinal Chemistry · 2001 · 112 citations · Full text

Compound 8, Immunology, Hiv-1 Inhibitors +20

Piperazine-Based CCR5 antagonists as HIV-1 inhibitors. I: 2(S)-methyl piperazine as a key pharmacophore element

Jayaram R. Tagat, Stuart W. McCombie, Ruo W. Steensma et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 65 citations · Full text

Medicinal Chemistry, Key Pharmacophore Element, Medicine +11

Concise Formation of 4-Benzyl Piperidines and Related Derivatives Using a Suzuki Protocol

Susan F. Vice, Tom Bara, Annette Bauer et al. · The Journal of Organic Chemistry · 2001 · 46 citations

Derivative (Chemistry), Related Derivatives, Concise Formation +10

Generation and in situ acylation of enaminone anions: a convenient synthesis of 3-carbethoxy-4(1H)-pyridinones and -4-pyrones and related compounds

Stuart W. McCombie, William A. Metz, Dennis V. Nazareno et al. · The Journal of Organic Chemistry · 1991 · 31 citations

Diversity Oriented Synthesis, Engineering, Altmetric Attention Score +13