Jiajun Yap

The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants

Jimin Yuan, Wan Hwa Ng, Paula Yeng Po Lam et al. · Oncogene · 2018 · 57 citations · Full text

Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis

Jimin Yuan, Wan Hwa Ng, Zizi Tian et al. · Science Signaling · 2018 · 53 citations

The stability of R-spine defines RAF inhibitor resistance: A comprehensive analysis of oncogenic BRAF mutants with in-frame insertion of αC-β4 loop

Jiajun Yap, R. N. V. Krishna Deepak, Zizi Tian et al. · Science Advances · 2021 · 26 citations · Full text

The AMPK inhibitor overcomes the paradoxical effect of RAF inhibitors through blocking phospho–Ser-621 in the C terminus of CRAF

Jimin Yuan, Wan Hwa Ng, Jiajun Yap et al. · Journal of Biological Chemistry · 2018 · 17 citations · Full text

BRAF(V600E) mutation together with loss of Trp53 or pTEN drives the origination of hairy cell leukemia from B-lymphocytes

Jiajun Yap, Jimin Yuan, Wan Hwa Ng et al. · Molecular Cancer · 2023 · 12 citations · Full text