Carnosic Acid and Carnosol, Phenolic Diterpene Compounds of the Labiate Herbs Rosemary and Sage, are Activators of the Human Peroxisome Proliferator-Activated Receptor Gamma

Oliver Rau, Mario Wurglics, Alexander Paulke, +6

Planta Medica

Chemoprevention StrategyLipid PeroxidationPolyphenolicsOxidative StressGal4-ppargamma Fusion Receptor +14

Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes

Daniel Poeckel, Christine Greiner, Moritz Verhoff, +6

Biochemical Pharmacology

InflammationAnti-inflammatoryOxysterolMedicineLipid Peroxidation +7

Peroxisome Proliferator–Activated Receptor γ as a Molecular Target of Resveratrol-Induced Modulation of Polyamine Metabolism

Sandra Ulrich, Stefan Loitsch, Oliver Rau, +4

Cancer Research

Screening of herbal extracts for activation of the human peroxisome proliferator-activated receptor.

Oliver Rau, Mario Wurglics, Theo Dingermann, +2

PubMed

AllergyBiochemistryMedicineHerbal ExtractsPhysiology +10

Plant derived omega-3-fatty acids protect mitochondrial function in the brain

Gunter P. Eckert, Cornelia Franke, Michael Nöldner, +4

Pharmacological Research

Mitochondrial FunctionBiochemistryOmega-3 Fatty AcidLipid PeroxidationPhysiology +5

From Machine Learning to Natural Product Derivatives that Selectively Activate Transcription Factor PPARγ

Matthias Rupp, Timon Schroeter, Ramona Steri, +9

ChemMedChem

Structure‐Based Pharmacophore Screening for Natural‐Product‐Derived PPARγ Agonists

Yusuf Tanrıkulu, Oliver Rau, Oliver Schwarz, +5

ChemBioChem

α‐Alkyl Substituted Pirinixic Acid Derivatives as Potent Dual Agonists of the Peroxisome Proliferator Activated Receptor Alpha and Gamma

Oliver Rau, Yvonne Syha, Heiko Zettl, +3

Archiv der Pharmazie

Lipid PeroxidationPotent Dual AgonistsPharmacotherapyOxidative StressMolecular Pharmacology +16

An Innovative Method To Study Target Protein−Drug Interactions by Mass Spectrometry

Mathias Q. Müller, Leo J. de Koning, Andreas Schmidt, +6

Journal of Medicinal Chemistry

Drug TargetBiological Mass SpectrometryConformational ChangesSystem PharmacologyChemical Biology +17

From Molecular Shape to Potent Bioactive Agents II: Fragment‐Based de novo Design

Ewgenij Proschak, Kerstin Sander, Heiko Zettl, +6

ChemMedChem

Combinatorial ChemistryDrug TargetFragment-based Drug DesignMolecular BiologyLead Identification +18