Yoshihiro Kume

Inhibitory effects of quinolone antibacterial agents on gamma-aminobutyric acid binding to receptor sites in rat brain membranes

Ai Tsuji, Hitoshi Sato, Yoshihiro Kume et al. · Antimicrobial Agents and Chemotherapy · 1988 · 156 citations

Gamma-aminobutyric Acid, Neurotransmitter, Pharmacotherapy +22

Kinetic analysis of AUC-dependent saturable clearance of liposomes: Mathematical description of AUC dependency

Hideyoshi Harashima, Chizu Yamane, Yoshihiro Kume et al. · Journal of Pharmacokinetics and Biopharmaceutics · 1993 · 54 citations

Proteinlipid Interaction, Auc Dependency, Biochemistry +7

Saturable, Non-Michaelis-Menten Uptake of Liposomes by the Reticuloendothelial System

Yoshihiro Kume, Fumiyo Maeda, Hideyoshi Harashima et al. · Journal of Pharmacy and Pharmacology · 1991 · 34 citations

Multilamellar Vesicles, Extracellular Microvesicles, Cytoskeleton +18

Non-Michaelis–Menten Type Hepatic Uptake of Liposomes in the Rat

Hideyoshi Harashima, Yoshihiro Kume, Chizu Yamane et al. · Journal of Pharmacy and Pharmacology · 1992 · 22 citations

Saturable Hepatic Uptake, Determinant Parameter, Biomedical Engineering +18

Kinetic modeling of liposome degradation in blood circulation

Hideyoshi Harashima, Yoshihiro Kume, Chizu Yamane et al. · Biopharmaceutics & Drug Disposition · 1993 · 14 citations

Biomedical Engineering, Lipid Movement, Physiologically-based Pharmacokinetic Modeling +17